monoclonal-antibody

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

1. 66/100

   Estimating the eligible population for amyloid-targeting monoclonal antibody therapy in memory clinics: Application to lecanemab in France

   ✓ Peer-reviewed alzhub usefulness score 66 out of 100. The journal of prevention of Alzheimer's disease · 2026-10-14 · Treatments

   Lecanemab was the first amyloid-targeting monoclonal antibody approved by the European Commission for treating patients with mild cognitive impairment (MCI) and mild dementia due to Alzheimer's disease (AD).

   • Treatments
   • Care Services
   • Biomarkers
2. 83/100

   Incidence, severity, and associated risk factors for amyloid-related imaging abnormalities in anti-amyloid monoclonal antibody therapy for early Alzheimer's disease: a systematic review and meta-analysis

   ✓ Peer-reviewed alzhub usefulness score 83 out of 100. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026-10-02 · Treatments

   ARIA remains a significant safety concern in anti-amyloid mAb therapy, with incidence and severity influenced by genetic, neuroimaging, and treatment-related factors.

   • Treatments
   • Risk Factors
   • Side Effects
3. 76/100

   Efficacy and safety of lecanemab monoclonal antibody in the treatment of mild to moderate Alzheimer's disease: a systematic review and meta-analysis

   ✓ Peer-reviewed alzhub usefulness score 76 out of 100. Frontiers in pharmacology · 2026-09-28 · Treatments

   Lecanemab slowed cognitive decline versus placebo in mild-to-moderate AD by ADCOMS, CDR-SB, and ADAS-Cog.

   • Treatments
   • Clinical Trials
   • Side Effects
4. 50/100

   Prospective evaluation of systemic coagulation function during anti-amyloid monoclonal antibody therapy in Alzheimer's disease

   ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Journal of thrombosis and thrombolysis · 2026-08-20 · Treatments

   Anti-amyloid monoclonal antibodies such as lecanemab are increasingly used to treat Alzheimer's disease (AD) and are associated with amyloid-related imaging abnormalities (ARIA), including hemorrhagic findings (ARIA-H).

   • Treatments
5. 78/100

   Real-world effectiveness of monoclonal antibody lecanemab versus acetylcholinesterase inhibitors in Alzheimer's disease: a target trial emulation

   ✓ Peer-reviewed alzhub usefulness score 78 out of 100. Alzheimer's research & therapy · 2026-06-22 · Treatments

   Compared with an AChEI-based conventional care strategy, lecanemab initiation was associated with comparable treatment persistence and lower observed risks of BPSD, emergency visit as well as reduced use of psychotropic and infection-related medications in exploratory analyses.

   • Treatments
   • Clinical Trials
   • Side Effects
6. 47/100

   The clinical value of multimodal neuroimaging in monoclonal antibody therapy for Alzheimer's disease

   ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Frontiers in neurology · 2026-05-08 · Treatments

   Multimodal neuroimaging plays an indispensable role in the diagnosis, monitoring, and therapeutic evaluation of monoclonal antibody (mAb) therapies for Alzheimer's disease (AD).

   • Treatments
   • Brain Scans
   • Side Effects
7. 47/100

   Anti-Aβ3-10 monoclonal antibody 7B8 improves cognitive function and protects the blood-brain barrier in APP/PS1 mice by regulating the HMGB-1/RAGE/NF-κB pathway

   ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Frontiers in immunology · 2026-04-30 · Treatments

   7B8 effectively alleviates cognitive impairment and clears cerebral and perivascular amyloid deposits in young APP/PS1 mice with early-stage AD pathology and minimal CAA, with no increased risk of microhemorrhage in this experimental setting.

   • Brain Biology
   • Treatments
   • Digital Tools
8. 45/100

   [Amyloid-Related Imaging Abnormalities in Anti-Amyloid Monoclonal Antibody Therapy for Alzheimer's Disease: Expert Recommendation for Standard MRI Protocol]

   ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of the Korean Society of Radiology · 2025-01-24 · Treatments

   The introduction of anti-amyloid therapies for Alzheimer's disease (AD), such as lecanemab (Lequembi ® ), which was recently approved in Korea, necessitates careful monitoring for amyloid-related imaging abnormalities (ARIA) using brain MRI.

   • Treatments
   • Brain Scans
   • Side Effects

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