mk6240

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

1. 47/100

   Discriminative binding of tau PET tracers PI2620, MK6240 and RO948 in Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy brains

   ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Molecular psychiatry · 2022-11-29 · Brain scans and imaging

   Recent mechanistic and structural studies have challenged the classical tauopathy classification approach and revealed the complexity and heterogeneity of tau pathology in Alzheimer's disease (AD) and primary tauopathies such as corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), progressing beyond distinct tau isoforms.

   • Brain Scans
2. 67/100

   The Association of Age-Related and Off-Target Retention with Longitudinal Quantification of [18F]MK6240 Tau PET in Target Regions

   ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022-11-17 · Brain scans and imaging

   Inferior cerebellar gray matter SUV did not differ on the basis of diagnosis and amyloid-β status, cross-sectionally and over time. [ 18 F]MK6240 uptake significantly differed between CUY and CU adults in the putamen or pallidum (affecting ∼75% of the region) and in the Braak II region (affecting ∼35%).

   • Brain Scans
3. 47/100

   Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum

   ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) · 2022-04-05 · Brain scans and imaging

   Plasma p217+tau levels elevate early in the AD continuum and correlate well with Aβ and tau PET.

   • Brain Scans
4. 43/100

   Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240 tau-PET

   ✓ Peer-reviewed alzhub usefulness score 43 out of 100. EBioMedicine · 2022-02-06 · Brain scans and imaging

   The threshold for positivity was 15.085 pg/mL for plasma pTau181 and 17.652 pg/mL for plasma pTau231.

   • Biomarkers
   • Brain Scans
5. 52/100

   A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis

   ✓ Peer-reviewed alzhub usefulness score 52 out of 100. European journal of nuclear medicine and molecular imaging · 2021-05-27 · Brain scans and imaging

   The temporal meta-ROI can be used for differential diagnosis of dementia patients with [ 18 F]flortaucipir, [ 18 F]RO948, and [ 18 F]MK6240 tau PET with high accuracy, and that using very similar cut-offs of around 1.35 SUVR.

   • Brain Scans
   • Diagnosis
6. 43/100

   Characterization of MK6240, a tau PET tracer, in autopsy brain tissue from Alzheimer's disease cases

   ✓ Peer-reviewed alzhub usefulness score 43 out of 100. European journal of nuclear medicine and molecular imaging · 2020-09-24 · Brain scans and imaging

   3 H-MK6240 has a high binding affinity for tau deposits in AD brain tissue but also has different binding characteristics from those of the first-generation tau tracers.

   • Brain Scans
   • Brain Biology

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