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Home › Research › Topics › mendelian-randomization

mendelian-randomization

12 studies tagged mendelian-randomization, dated 2017-10-19 to 2023-05-13. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Exploring the possible causal effects of cardiac blood biomarkers in dementia and cognitive performance: a Mendelian randomization study 2023-05-13
  2. Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Cognitive Function 2022-08-01
  3. COVID-19 and risk of neurodegenerative disorders: A Mendelian randomization study 2022-07-14

Studies

12 studies carry this tag.

Date range

2017 to 2023

Top journals

  • Translational psychiatry 2
  • Alzheimer's research & therapy 1
  • GeroScience 1
  • International journal of epidemiology 1
  • Journal of Alzheimer's disease : JAD 1

11 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Exploring the possible causal effects of cardiac blood biomarkers in dementia and cognitive performance: a Mendelian randomization study

    ✓ Peer-reviewed alzhub usefulness score 71 out of 100. GeroScience 2023-05-13 Biomarkers

    Prospective cohort studies have implied associations between blood levels of troponin T, troponin I, NT-proBNP, GDF15, dementia, and cognitive function, without providing evidence favoring possible causality.

  2. Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Cognitive Function

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Journal of the American College of Cardiology 2022-08-01 Genetics

    Using a wide range of cognitive function and dementia endpoints, we failed to find genetic evidence of an adverse PCSK9-related impact, suggesting a neutral cognitive profile.

  3. COVID-19 and risk of neurodegenerative disorders: A Mendelian randomization study

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Translational psychiatry 2022-07-14 Genetics

    Emerging evidence has suggested a close correlation between COVID-19 and neurodegenerative disorders.

  4. CSF sTREM2 in neurological diseases: a two-sample Mendelian randomization study

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Journal of neuroinflammation 2022-04-05 TREM2 and immune genetics

    These findings provide support for a potential causal relationship between elevated CSF sTREM2 levels and higher risk of multiple sclerosis.

  5. Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

    ✓ Peer-reviewed alzhub usefulness score 91 out of 100. eLife 2022-03-29 Genetics

    Meta-analysed IVW MR findings suggested that higher GrimAge acceleration increased the risk of colorectal cancer (OR = 1.12 per year increase in GrimAge acceleration, 95% CI 1.04-1.20, p = 0.002).

  6. Investigating Casual Associations Among Gut Microbiota, Metabolites, and Neurodegenerative Diseases: A Mendelian Randomization Study

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Journal of Alzheimer's disease : JAD 2022-01-01 Genetics

    Our study firstly applied a two-sample MR approach to detect causal relationships among gut microbiota, gut metabolites, and neurodegenerative diseases.

  7. Herpesvirus infections and Alzheimer's disease: a Mendelian randomization study

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's research & therapy 2021-09-24 Genetics

    Our findings provided evidence supporting a positive relationship between mononucleosis and AD, indicating a causal link between EBV infection and AD.

  8. Cortical structure and the risk for Alzheimer's disease: a bidirectional Mendelian randomization study

    ✓ Peer-reviewed alzhub usefulness score 83 out of 100. Translational psychiatry 2021-09-15 Genetics

    Progressive loss of neurons in a specific brain area is one of the manifestations of Alzheimer's disease (AD).

  9. Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2021-04-01 Genetics

    There are currently no disease-modifying treatments for Alzheimer's disease (AD), and an understanding of preclinical causal biomarkers to help target disease pathogenesis in the earliest phases remains elusive.

  10. Sleep, major depressive disorder, and Alzheimer disease: A Mendelian randomization study

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Neurology 2020-08-19 Genetics

    We found that AD may causally influence sleep patterns.

  11. Repurposing antihypertensive drugs for the prevention of Alzheimer's disease: a Mendelian randomization study

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of epidemiology 2020-08-01 Genetics

    Mendelian randomization suggests that lowering systolic blood pressure via the protein targets of antihypertensive drugs is unlikely to affect the risk of developing Alzheimer's disease.

  12. Branched-chain amino acids and Alzheimer's disease: a Mendelian randomization analysis

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Scientific reports 2017-10-19 Genetics

    We conducted a two-sample Mendelian randomization study to test the hypothesis that raised plasma levels of the branched-chain amino acids isoleucine, leucine, and valine are associated with Alzheimer's disease (AD).

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