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Newest in this topic

  1. Individual Angiotensin Receptor Blockers and Risk of Dementia: A Target Trial Emulation Study 2026-10-14
  2. Dementia and PDE5 inhibitors: A retrospective cohort study of veterans 2026-10-13
  3. The influence of cognitive decline on the severity and quantity of drug-drug interactions 2026-10-11

Studies

271 studies carry this tag.

Date range

1981 to 2026

Top journals

  • Journal of Alzheimer's disease : JAD 15
  • Neurology 11
  • Journal of the American Geriatrics Society 9
  • Research Square 8
  • medRxiv 8

138 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. A randomized, controlled trial of linopirdine in the treatment of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 75 out of 100. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1997-05 Clinical trials

    No difference was seen in Clinical Global Impression scores between patients receiving placebo and those receiving linopirdine (n = 189).

  2. The cognitive effects of recombinant interleukin-2 (rIL-2) therapy: a controlled clinical trial using computerised assessments

    ✓ Peer-reviewed alzhub usefulness score 71 out of 100. European journal of cancer (Oxford, England : 1990) 1996-12-01 Cognitive tests and assessment

    It has been suggested that patients undergoing treatment with recombinant interleukin-2 (rIL-2) may develop cognitive impairment.

  3. This study evaluated the efficacy and safety of donepezil in patients with mild to moderately severe Alzheimer's disease, and examined the relationships between plasma donepezil concentration, red blood cell acetylcholinesterase (AChE) activity and clinical response.

  4. The efficacy of the ginkgo biloba special extract EGb 761 in outpatients with presenile and senile primary degenerative dementia of the Alzheimer type (DAT) and multi-infarct dementia (MID) according to DSM-III-R was investigated in a prospective, randomized, double-blind, placebo-controlled, multi-center study.

  5. One hundred years of schizophrenia: a meta-analysis of the outcome literature

    ✓ Peer-reviewed alzhub usefulness score 79 out of 100. The American journal of psychiatry 1994-10-01 Getting a diagnosis

    Overall, less than half of patients diagnosed with schizophrenia have shown substantial clinical improvement after follow-up averaging nearly 6 years.

  6. Hepatotoxic Effects of Tacrine Administration in Patients With Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. JAMA 1994-04-06 How common it is

    Among the 2446 patients who received tacrine in clinical trials, ALT levels greater than the upper limit of normal (ULN) occurred on at least one occasion in 1203 patients (49%), ALT levels greater than three times the ULN occurred in 621 patients (25%), and ALT levels greater than 20 times the ULN occurred in 40 patients (2%).

  7. A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The Tacrine Study Group

    ✓ Peer-reviewed alzhub usefulness score 79 out of 100. JAMA 1994-04-01 Clinical trials

    Tacrine produced statistically significant, dose-related improvements on objective performance-based tests, clinician- and caregiver-rated global evaluations, and measures of quality of life.

  8. Clinical trial of indomethacin in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Neurology 1993-08-01 Clinical trials

    In a 6-month, double-blind, placebo-controlled study, 100 to 150 mg/d indomethacin appeared to protect mild to moderately impaired Alzheimer's disease patients from the degree of cognitive decline exhibited by a well-matched, placebo-treated group.

  9. A controlled trial of tacrine in Alzheimer's disease. The Tacrine Study Group

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. JAMA 1992-11-01 Clinical trials

    These results confirm the efficacy and safety of tacrine in some patients with Alzheimer's disease.

  10. A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. The New England journal of medicine 1992-10-01 Treatments

    In this short-term study in patients with Alzheimer's disease who were selected for apparent responsiveness to tacrine, treatment with tacrine resulted in a statistically significant reduction in the decline of cognitive function, although this reduction was not large enough to be detected by the study physicians' global assessments of the patients.

  11. Dementia: A Clinical Approach

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Annals of Internal Medicine 1992-08-15 Lewy body dementia

    1. Dementia: Significance, Definition, and Epidemiology 2.

  12. Explicit criteria for determining inappropriate medication use in nursing home residents. UCLA Division of Geriatric Medicine

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Archives of internal medicine 1991-09-01 Drug development

    Increasing attention is being paid to inappropriate medication use in nursing homes.

  13. The Clinical Efficacy of Citalopram in Treatment of Emotional Disturbances in Dementia Disorders a Nordic Multicentre Study

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The British Journal of Psychiatry 1990-12-01 Clinical trials

    In this multicenter study, the clinical efficacy of citalopram was investigated in 98 patients with moderate AD/SDAT or VD using a combined double-blind and open technique with placebo and citalopram.

  14. DGAVP (Org 5667) in early Alzheimer's disease patients: an international double-blind, placebo-controlled, multicenter trial

    ✓ Peer-reviewed alzhub usefulness score 73 out of 100. Neurology 1990-07 Clinical trials

    We carried out a double-blind study of a vasopressin-related peptide, DGAVP citrate (Org 5667), in 115 patients with mild dementia, probable Alzheimer's type (DAT).

  15. A metaanalysis of controlled trials of neuroleptic treatment in dementia

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Journal of the American Geriatrics Society 1990-05-01 Clinical trials

    Prior qualitative literature reviews about the use of neuroleptics in dementia suggest that they are "modestly effective" in treating agitation and that no single neuroleptic is better than another.

  16. Benzodiazepines of long and short elimination half-life and the risk of hip fracture

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. JAMA 1989-12-01 Health systems and care delivery

    To determine if the risk of hip fracture difference between persons receiving benzodiazepines with long (greater than or equal to 24 hours) or short (less than 24 hours) elimination half-lives, we conducted a nested case-control study among residents of the Canadian province of Saskatchewan who were 65 years of age and older.

  17. Adverse drug reactions associated with global cognitive impairment in elderly persons

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Annals of internal medicine 1987-08-01 Drug development

    Adverse drug reactions causing cognitive impairment are an important problem in the elderly.

  18. Behavioral symptoms in Alzheimer's disease: phenomenology and treatment

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PubMed 1987-05-01 Clinical safety

    Limited information is available regarding the incidence, nature, and treatment of behavioral problems in Alzheimer's disease (AD).

  19. Psychotropic drug use and the risk of hip fracture

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. The New England journal of medicine 1987-02-01 Clinical safety

    To assess the risk of hip fracture associated with the use of four classes of psychotropic drugs, we performed a case-control study of 1021 patients with hip fractures and 5606 controls among elderly Medicaid enrollees.

  20. Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type

    ✓ Peer-reviewed alzhub usefulness score 71 out of 100. The New England journal of medicine 1986-11-01 Clinical trials

    We treated 17 patients who had moderate to severe Alzheimer's disease with oral tetrahydroaminoacridine (THA), a centrally active anticholinesterase, in a three-phase study.

  21. Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The British Journal of Psychiatry 1981-01-01 Clinical trials

    Physostigmine (0.25 mg-1 mg), arecoline (2 and 4 mg) and saline were administered intravenously over 30 minutes in a randomized double blind design to 11 patients with a clinical diagnosis of Alzheimer presenile dementia.

From across this tag

9 of the 271 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts