alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Home › Research › Topics › mechanistic-insights

mechanistic-insights

2 studies tagged mechanistic-insights, dated 2020-02-27 to 2025-11-13. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Next-generation neurotherapeutics: mechanistic insights on monoclonal antibodies in Alzheimer's disease 2025-11-13
  2. Mechanistic insights into the deleterious roles of Nasu-Hakola disease associated TREM2 variants 2020-02-27

Studies

2 studies carry this tag.

Date range

2020 to 2025

Top journals

  • Brain research 1
  • Scientific reports 1

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Next-generation neurotherapeutics: mechanistic insights on monoclonal antibodies in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Brain research 2025-11-13 Treatments

    Monoclonal antibodies (mAbs) for Alzheimer's disease (AD) present a fundamental translational challenge, as demonstrated by amyloid-beta (Aβ)-targeting mAbs that successfully employed Fragment crystallizable gamma receptor (FcγR)/Immunoreceptor tyrosine-based activation motif (ITAM)-mediated microglial phagocytosis yet achieved only modest cognitive improvements while introducing significant Amyloid-related imaging abnormalities (ARIA) risk, thereby highlighting inherent single-therapy limitations.

  2. Mechanistic insights into the deleterious roles of Nasu-Hakola disease associated TREM2 variants

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Scientific reports 2020-02-27 TREM2 and immune genetics

    Recently, the critical roles played by genetic variants of TREM2 (Triggering Receptor Expressed on Myeloid cells 2) in Alzheimer's disease have been aggressively highlighted.

All topic tags with their study counts