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late-onset
5 studies tagged late-onset, dated 1997-10-01 to 2024-02-21. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease 2024-02-21
- Cerebrospinal Fluid and Plasma Biomarkers do not Differ in the Presenile and Late-Onset Behavioral Variants of Frontotemporal Dementia 2020-01-01
- White Matter Tract Integrity in Alzheimer's Disease vs. Late Onset Bipolar Disorder and Its Correlation with Systemic Inflammation and Oxidative Stress Biomarkers 2017-06-16
Studies
5 studies carry this tag.
Date range
1997 to 2024
Top journals
- Journal of Alzheimer's disease : JAD 2
- Alzheimer's & dementia : the journal of the Alzheimer's Association 1
- Frontiers in aging neuroscience 1
- Journal of neurology, neurosurgery, and psychiatry 1
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MTUS2 encodes a microtubule associated protein implicated in the development and function of the nervous system, making it a plausible candidate to investigate LOAD biology.
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The CSF and plasma biomarker profiles did not suggest a more aggressive neurodegeneration in the presenile group (comparable T-tau, NFL, and GFAP levels) or the co-existence of Alzheimer's disease in the late-onset group (comparable and within normal range CSF Aβ1-42 and P-tau).
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The TBSS contrasts with by ANOVA F -test has identified strongly significant clusters in the forceps minor, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and cingulum gyrus.
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The K311R mutation might contribute to AD pathogenesis by overproducing toxic Aβ species and enhancing tau phosphorylation.
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The deposition of insoluble beta-amyloid protein fibrils is probably the central event in the pathogenesis of Alzheimer's disease.