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inflammasome
384 studies tagged inflammasome, dated 1986-05-01 to 2026-11-01. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
Studies
384 studies carry this tag.
Date range
1986 to 2026
Top journals
- bioRxiv 21
- Journal of neuroinflammation 17
- International journal of molecular sciences 13
- Alzheimer's & dementia : the journal of the Alzheimer's Association 10
- Glia 10
169 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
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Alzheimer's disease is the most common form of dementia, accounting for as much as three-quarters of cases globally with individuals in low- and middle-income countries being worst affected.
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Alzheimer's disease (AD) is characterized by the presence of amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs), neuronal and synaptic loss and inflammation of the central nervous system (CNS).
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Inflammasomes are intracellular protein complexes, members of the innate immune system, and their activation and regulation play an essential role in maintaining homeostatic conditions against exogenous and endogenous stimuli.
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Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder with an alarming increasing prevalence.
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CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity.
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Approximately ten million people are diagnosed with dementia annually since they experience difficulties with memory and thinking skills.
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Alzheimer's disease is a type of dementia characterized by problems with short-term memory, cognition, and difficulties with activities of daily living.
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Physical exercise is generally beneficial to all aspects of human and animal health, slowing cognitive ageing and neurodegeneration 1 .
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Alzheimer's disease (AD) is a form of dementia characterized by progressive memory decline and cognitive dysfunction.
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Recent studies indicate that the adaptive immune system plays a role in Lewy body dementia (LBD).
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Alzheimer's disease (AD), an extremely common neurodegenerative disorder of the older generation, is one of the leading causes of death globally.
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The acetylcholinesterase inhibitors donepezil and rivastigmine have been used as therapeutic drugs for Alzheimer's disease (AD), but their effects on LPS- and Aβ-induced neuroinflammatory responses and the underlying molecular pathways have not been studied in detail in vitro and in vivo.
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Loss-of-function variants of triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk of developing Alzheimer's disease (AD).
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Microglia are the resident macrophages of the central nervous system (CNS) acting as the first line of defense in the brain by phagocytosing harmful pathogens and cellular debris.
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As resident immune cells of the brain, microglia serve pivotal roles in regulating neuronal function under both physiological and pathological conditions, including aging and the most prevalent neurodegenerative disease, Alzheimer's disease (AD).
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Classically, the following three morphological states of microglia have been defined: ramified, amoeboid and phagocytic.
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Rare coding variants of the microglial triggering receptor expressed on myeloid cells 2 (TREM2) confer an increased risk for Alzheimer's disease (AD) characterized by the progressive accumulation of aggregated forms of amyloid β peptides (Aβ).
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41/100
Alzheimer's disease (AD) is the most common progressive neurodegenerative disease.
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41/100
Alzheimer's disease (AD) is a neurodegenerative disorder with no clear causative event making the disease difficult to diagnose and treat.
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The NLRP3 inflammasome is a cytosolic multiprotein complex composed of the innate immune receptor protein NLRP3, adapter protein ASC, and inflammatory protease caspase-1 that responds to microbial infection, endogenous danger signals, and environmental stimuli.
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Alzheimer's disease (AD) is a neurodegenerative disease characterized by an increasing deterioration of memory, which is concomitant with additional cognitive deficits.
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The autophagy-lysosomal pathway plays a critical role in intracellular clearance and metabolic homeostasis.
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Amyloid beta (Aβ)-induced abnormal neuroinflammation is recognized as a major pathological feature of Alzheimer's disease (AD), which results in memory impairment.
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Clinical trials of new drugs for Alzheimer's disease (AD) have ended with disappointing results, with tremendous resources and time.
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Immune surveillance is an essential process that safeguards the homeostasis of a healthy brain.
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Neuroinflammation contributes to Alzheimer's disease (AD) progression.
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The role of microglia cells in Alzheimer's disease (AD) is well recognized, however their molecular and functional diversity remain unclear.
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Here, we demonstrated for the first time that CD3-CD122+NK1.1+ precursor NK (pNK) cells expressed TREM2 and their population increased in TREM2-overexpressing transgenic (TREM2-TG) mice compared with that in female C57BL/6 J wild type (WT) mice.
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41/100
Neurodegeneration is a debilitating condition that causes nerve cell degeneration or death.
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Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune cell surface receptor that regulates microglial function and is involved in the pathophysiology of several neurodegenerative diseases.
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41/100
Parkinson's disease is characterized by accumulation of α-synuclein (αSyn).
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The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapidly become an active area of research.
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Triggering receptor expressed on myeloid cells-2 (TREM2) and colony-stimulating factor 1 receptor (CSF1R) are crucial molecules for microgliopathy, which is characterized by microglia dysfunction and has recently been proposed as the neuropathological hallmark of neurological disorders.
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The innate immune system is a viable target for therapeutic intervention in AD.
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There is growing evidence that excessive microglial phagocytosis of neurons and synapses contributes to multiple brain pathologies.
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The prevalence of neurodegenerative disease has increased significantly in recent years, and with a rapidly aging global population, this trend is expected to continue.
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Microglia performs a variety of functions during brain development designed to maintain brain homeostasis.
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Excessive microglial activation might be a central pathological process in GRN-related frontotemporal dementia (FTD-GRN).
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The complement system is part of the innate immune system that comprises several small proteins activated by sequential cleavages.
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Alzheimer's disease (AD) is a lethal neurodegenerative disorder primarily affecting the aged population.
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Variants in the triggering receptor expressed on myeloid cells 2 gene are linked with an increased risk of dementia, in particular the R47Hhet triggering receptor expressed on myeloid cells 2 variant is linked to late-onset Alzheimer's disease.
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Inflammation plays important roles in the progress of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease.
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Microglia, resident immune cells of the central nervous system (CNS), play a pivotal role in immune surveillance and maintenance of neuronal health.
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Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty 1-3 .
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The innate immune system plays key roles in controlling Alzheimer's disease (AD), while secreting cytokines to eliminate pathogens and regulating brain homeostasis.
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Alzheimer's Disease (AD) is the most prevalent form of dementia across the world.
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Alzheimer's disease (AD) is the main cause of dementia worldwide.
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Alzheimer's disease (AD) is the most prevalent neurodegenerative disease commonly diagnosed among the elderly population.
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Alzheimer's disease (AD) is the most common form of dementia.
From across this tag
8 of the 384 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.
- Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention
- The TREM2 H157Y Variant Influences Microglial Phagocytosis, Polarization, and Inflammatory Cytokine Release
- Neurovascular Inflammaging in Health and Disease
- Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model
- The Emerging Roles and Therapeutic Potential of Soluble TREM2 in Alzheimer's Disease
- Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice
- Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
- Tumor necrosis factor identified in multiple sclerosis brain