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immune
6 studies tagged immune, dated 2016-07-26 to 2025-03-27. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
Studies
6 studies carry this tag.
Date range
2016 to 2025
Top journals
- Frontiers in aging neuroscience 2
- Acta neuropathologica 1
- Molecular neurodegeneration 1
- Nature genetics 1
- Neurology. Genetics 1
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Alzheimer's disease (AD) is a widespread neurodegenerative disorder and one of the major challenges for public health.
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Alzheimer's disease (AD) is marked by the presence of amyloid beta (Aβ) plaques, neurofibrillary tangles (NFT), neuronal death and synaptic loss, and inflammation in the brain.
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Immune-disease-associated variants are enriched in active chromatin regions of T cells and macrophages.
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Our results were also contrasted with existing proteomic data from wild-type mouse microglia and from existing microglial transcriptomic data from wild-type and 5xFAD mice.
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Immune privilege of the central nervous system (CNS) has been ascribed to the presence of a blood-brain barrier and the lack of lymphatic vessels within the CNS parenchyma.
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We find that the rs12456492 PD risk variant affects expression of AD-associated protein CD33 in peripheral monocytes, which suggests that genetic factors for these 2 diseases may converge to influence overlapping innate immune-mediated mechanisms that contribute to neurodegeneration.