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homeostatic
2 studies tagged homeostatic, dated 2011-01-01 to 2012-07-20. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
Studies
2 studies carry this tag.
Date range
2011 to 2012
Top journals
- Journal of Alzheimer's disease : JAD 1
- Pharmacology & therapeutics 1
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Low-density lipoprotein receptor-related protein-1 (LRP1) is the main cell surface receptor involved in brain and systemic clearance of the Alzheimer's disease (AD) toxin amyloid-beta (Aβ).
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In this article, we propose that impaired efficiency of glutamatergic synaptic transmission and a compensatory reduction in inhibitory neurotransmission, a process called homeostatic disinhibition, occurs in the aging brain and more dramatically in Alzheimer's disease (AD).