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Home › Research › Topics › gwas

gwas

11 studies tagged gwas, dated 2008-09-29 to 2023-05-11. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. CARMA is a new Bayesian model for fine-mapping in genome-wide association meta-analyses 2023-05-11
  2. GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia 2022-01-13
  3. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study 2018-04-30

Studies

11 studies carry this tag.

Date range

2008 to 2023

Top journals

  • Molecular psychiatry 2
  • Nature genetics 2
  • BMC medical genomics 1
  • Current neurology and neuroscience reports 1
  • Neurobiology of aging 1

9 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. CARMA is a new Bayesian model for fine-mapping in genome-wide association meta-analyses

    ✓ Peer-reviewed alzhub usefulness score 71 out of 100. Nature genetics 2023-05-11 Genetics

    Fine-mapping is commonly used to identify putative causal variants at genome-wide significant loci.

  2. GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. eLife 2022-01-13 Genetics

    Our genetic findings indicate that mtDNA-CN is a complex biomarker reflecting specific MT processes related to mtDNA regulation, and that these processes are causally related to human diseases.

  3. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study

    ✓ Peer-reviewed alzhub usefulness score 78 out of 100. The Lancet. Neurology 2018-04-30 Genetics

    The effect of genome-wide significant variants at the GFRA2 locus on expression of GFRA2 was assessed using mRNA expression studies in cerebellar tissue samples from the Mayo Clinic brain bank.

  4. Four Genome-Wide Association Studies Identify New Extreme Longevity Variants

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. The journals of gerontology. Series A, Biological sciences and medical sciences 2017-10-01 Genetics

    The search for the genetic determinants of extreme human longevity has been challenged by the phenotype's rarity and its nonspecific definition by investigators.

  5. GWAS for executive function and processing speed suggests involvement of the CADM2 gene

    ✓ Peer-reviewed alzhub usefulness score 79 out of 100. Molecular psychiatry 2015-04-14 Genetics

    To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium.

  6. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. PLoS genetics 2014-10-23 Genetics

    Cerebrospinal fluid (CSF) 42 amino acid species of amyloid beta (Aβ42) and tau levels are strongly correlated with the presence of Alzheimer's disease (AD) neuropathology including amyloid plaques and neurodegeneration and have been successfully used as endophenotypes for genetic studies of AD.

  7. Genome-wide association studies in Alzheimer's disease: a review

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current neurology and neuroscience reports 2013-10-01 Genetics

    Over the past decade, research aiming to disentangle the genetic underpinnings of late-onset Alzheimer's disease has mostly focused on the identification of common variants through genome-wide association studies.

  8. A genome-wide association study of aging

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Neurobiology of aging 2011-07-22 Genetics

    Human longevity and healthy aging show moderate heritability (20%-50%).

  9. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Molecular psychiatry 2010-11-30 Genetics

    Alzheimer's disease (AD) is a progressive neurodegenerative disorder with considerable evidence suggesting an initiation of disease in the entorhinal cortex and hippocampus and spreading thereafter to the rest of the brain.

  10. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Nature genetics 2009-09-06 Genetics

    The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease.

  11. A genome-wide association study for late-onset Alzheimer's disease using DNA pooling

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. BMC medical genomics 2008-09-29 Genetics

    We have validated the pooling method for GWA studies by both identifying the APOE locus and by observing a strong enrichment for significantly associated SNPs.

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