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Newest in this topic

  1. Valproate reduces tau phosphorylation via cyclin-dependent kinase 5 and glycogen synthase kinase 3 signaling pathways 2011-03-22
  2. Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage 2011-01-13
  3. Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau 1998-08-01

Studies

4 studies carry this tag.

Date range

1998 to 2011

Top journals

  • Biochimica et biophysica acta 1
  • Brain research bulletin 1
  • Neuroscience 1
  • Proceedings of the National Academy of Sciences of the United States of America 1

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Valproate reduces tau phosphorylation via cyclin-dependent kinase 5 and glycogen synthase kinase 3 signaling pathways

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research bulletin 2011-03-22 Drug development

    Valproate (VPA) is a widely used anticonvulsant and mood-stabilizing drug.

  2. Presenilin 1 (PS1), a causative molecule of familial Alzheimer's disease (AD), is known to be an unprimed substrate of glycogen synthase kinase 3 β (GSK3β) [Twomey and McCarthy (2006) FEBS Lett 580:4015-4020] and is phosphorylated at serine 353, 357 residues in its cytoplasmic loop region [Kirschenbaum et al. (2001) J Biol Chem 276:7366-7375].

  3. Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1998-08-01 Risk genes beyond APOE

    Families bearing mutations in the presenilin 1 (PS1) gene develop Alzheimer's disease.

  4. Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochimica et biophysica acta 1998-04-01 Drug development

    One of the histopathological markers in Alzheimer's disease is the accumulation of hyperphosphorylated tau in neurons called neurofibrillary tangles (NFT) composing paired helical filaments (PHF).

All topic tags with their study counts