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genome-wide
346 studies tagged genome-wide, dated 1992-10-01 to 2026-10-26. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
Studies
346 studies carry this tag.
Date range
1992 to 2026
Top journals
- Alzheimer's & dementia : the journal of the Alzheimer's Association 29
- Neurobiology of aging 18
- Journal of Alzheimer's disease : JAD 16
- Molecular psychiatry 12
- medRxiv 11
137 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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The high prevalence of Alzheimer's disease (AD) among the elderly population and its lack of effective treatments make this disease a critical threat to human health.
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Although abnormal accumulation of amyloid in the brain is an early biomarker of Alzheimer's disease (AD), wide variation in cognitive trajectories during life can be seen in the setting of brain amyloidosis, ranging from maintenance of normal function to progression to dementia.
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Late-onset Alzheimer's disease (LOAD), the most common cause of dementia, and a huge global health challenge, is a neurodegenerative disease of uncertain aetiology.
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Alzheimer's disease (AD) is the most common senile neurodegenerative disease characterized by progressive cognitive dysfunction, psychological and behavioral abnormalities, and impaired ability of activities of daily living.
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A multi-stage variable selection method is introduced for detecting association signals in structured brain-wide and genome-wide association studies (brain-GWAS).
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Genome-wide association studies have discovered numerous genomic loci associated with Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified.
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Recent genetic progress allows the molecular diagnosis of young-onset dementia, including Alzheimer's disease (AD) and frontotemporal dementia (FTD).
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Large studies (e.g. UK Biobank) are increasingly used for GWAS and Mendelian randomization (MR) studies.
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Genome-wide association studies (GWAS) have identified many risk loci for Alzheimer's disease (AD) 1,2 , but how these loci confer AD risk is unclear.
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In this paper, we used the MGAS (Multivariate Gene-based Association test by extended Simes procedure) tool to perform multivariate GWAS on eight AD-relevant subcortical imaging measures.
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The primary genetic risk factor for late onset Alzheimer's disease (LOAD) is the APOE4 allele of Apolipoprotein E (APOE) gene.
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66/100
Amyotrophic lateral sclerosis (ALS) is a multi-system disease characterized primarily by progressive muscle weakness.
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Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the most common form of dementia in the elderly.
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PheMap significantly streamlines the process of extracting research-quality phenotype information from EHRs, with comparable or better performance to current phenotyping approaches.
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43/100
Alzheimer's disease (AD) disproportionately affects certain racial and ethnic subgroups, such as African American/Black and Hispanic adults.
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Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer's disease (LOAD).
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Alzheimer's disease is the most frequent diagnosis of neurodegenerative dementia with early (≤65 years) and late (>65 years) onset ages in familial and sporadic patients.
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In the clinical diagnosis of dementia with Lewy bodies, distinction from Alzheimer's disease is suboptimal and complicated by shared genetic risk factors and frequent co-pathology.
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Estimated mean survival was 11.6 (10.4-12.9) years and was similar for APP and PSEN1 mutations.
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Genetically predisposition to longer educational attainment and harder math class taken were associated with significantly lower statistical odds ratio of ALS.
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AD genetic risk and two dementia risk scores were associated with differential methylation.
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SORL1 is associated with AD in the Hong Kong Chinese population.
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Approximately 30% of older adults exhibit the neuropathological features of Alzheimer's disease without signs of cognitive impairment.
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66/100
Most people's cognitive abilities decline with age, with significant and partly genetically driven, individual differences in rate of change.
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50/100
Genome wide association studies (GWAS) of human diseases have generally identified many loci associated with risk with relatively small effect sizes.
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The novel respiratory disease COVID-19 produces varying symptoms, with fever, cough, and shortness of breath being common.
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In this paper we explore the phenomenon of pleiotropy in neurodegenerative diseases, focusing on Alzheimer's disease (AD).
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We identified 11 loci-5 in H2-non-carriers and 6 in H2-carriers-although none of the MAPT haplotype-specific associations achieved genome-wide significance.
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Sortilin-related receptor 1 (SORL1) encodes a large, multi-domain containing, membrane-bound receptor involved in endosomal sorting of proteins between the trans-Golgi network, endosomes and the plasma membrane.
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55/100
Extensive simulations demonstrated that the proposed approach not only provided accurate selection of single nucleotide polymorphisms (SNPs) with comparable or higher power but also robust control of false positives.
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Presenilin1 (PSEN1) gene is the most common known genetic cause of early-onset familial Alzheimer's disease.
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Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive dysfunction and behavioral impairment.
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Although Alzheimer's disease (AD) is a central nervous system disease and type 2 diabetes MELLITUS (T2DM) is a metabolic disorder, an increasing number of genetic epidemiological studies show clear link between AD and T2DM.
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Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability of 58-79% and early-onset AD showing over 90%.
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In this regard, this study presents GenEpi, a computational package to uncover epistasis associated with phenotypes by the proposed machine learning approach.
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Alzheimer's disease (AD) is a neurodegenerative disease that is clinically characterized by progressive cognitive decline.
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Variations in the human genome have been found to be an essential factor that affects susceptibility to Alzheimer's disease.
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This situation presents difficulties for experimental studies, drug development, and other future research.
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Preclinical models of Alzheimer's disease (AD) suggest APOE modulates brain function in structures vulnerable to AD pathophysiology.
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Variants in GBA, encoding the enzyme glucocerebrosidase, are associated with Lewy body diseases such as Parkinson's disease and Lewy body dementia.
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We identified rs13374761-A in SLAMF1 gene associated with less memory decline (MAF = 0.071, β= 0.0103, p = 4.14×10-8).
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From The Cancer Genome Atlas (TCGA) database, we found 1,643 somatic mutations in the APP, PSEN1, PSEN2, MAPT, SNCA and LRRK2 genes in cancer patients.
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46/100
A splice mutation (p.S290C) in PSEN1 and a missense mutation (p.V717I) in APP were identified.
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Alzheimer's disease (AD) has a very strong genetic component, whose characterization has become an essential part of efforts to understand the pathophysiological processes of the disease.
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Hippocampal atrophy rate has been correlated with cognitive decline and its genetic modifiers are still unclear.
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Ventricular enlargement occurs in several neurodegenerative and psychiatric diseases.
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Two novel SNPs (rs465401 and rs460420), both near the ADAMTS1 gene on chromosome 21, showed genome-wide significant associations with CSF NFL.
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Prediction of disease risk is an essential part of preventative medicine, often guiding clinical management.
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Alzheimer's disease (AD) is the most common form of dementia.
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It is estimated that the impact of related genes on the risk of Alzheimer's disease (AD) is nearly 70%.
From across this tag
8 of the 346 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.
- Expression predictions inform molecular interpretation of Alzheimer’s disease risk loci
- Variable expression of familial Alzheimer disease associated with presenilin 2 mutation M239I
- Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
- Polygenic Risk Scores in Alzheimer's Disease Genetics: Methodology, Applications, Inclusion, and Diversity
- Orthogonal Contributions of Genetic, Clinical, and Social Determinants of Health Risk Burdens on Alzheimer’s Disease Pathophysiology
- Associating genes and protein complexes with disease via network propagation
- Molecular genetics of early-onset Alzheimer's disease revisited
- Combinational Drug Repurposing from Genetic Networks Applied to Alzheimer's Disease