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Home › Research › Topics › gene-cluster

gene-cluster

4 studies tagged gene-cluster, dated 2011-05-31 to 2018-03-15. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology 2018-03-15
  2. Mutation analysis of the MS4A and TREM gene clusters in a case-control Alzheimer's disease data set 2016-03-21
  3. Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease 2015-09-01

Studies

4 studies carry this tag.

Date range

2011 to 2018

Top journals

  • Alzheimer's & dementia : the journal of the Alzheimer's Association 1
  • Genome medicine 1
  • Molecular psychiatry 1
  • Neurobiology of aging 1

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

    ✓ Peer-reviewed alzhub usefulness score 81 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2018-03-15 Genetics

    We present robust evidence for elevated DNA methylation associated with Alzheimer's disease neuropathology spanning the HOXA gene cluster on chromosome 7.

  2. Mutation analysis of the MS4A and TREM gene clusters in a case-control Alzheimer's disease data set

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurobiology of aging 2016-03-21 TREM2 and immune genetics

    Genome wide association studies have identified an association between Alzheimer's disease (AD) and common polymorphisms in the MS4A and TREM loci (each containing a cluster of homologous genes) and should be thoroughly investigated for the presence of potentially functional variations.

  3. Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Molecular psychiatry 2015-09-01 Genetics

    We have sequenced the complete genomes of 72 individuals affected with early-onset familial Alzheimer's disease caused by an autosomal dominant, highly penetrant mutation in the presenilin-1 (PSEN1) gene, and performed genome-wide association testing to identify variants that modify age at onset (AAO) of Alzheimer's disease.

  4. The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 79 out of 100. Genome medicine 2011-05-31 Genetics

    Our results underscore the importance of international efforts combining GWAS datasets to isolate genetic loci for complex diseases.

All topic tags with their study counts