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Home › Research › Topics › gamma-secretase-activity

gamma-secretase-activity

3 studies tagged gamma-secretase-activity, dated 2000-08-01 to 2006-01-09. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms 2006-01-09
  2. Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains 2002-02-01
  3. L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity 2000-08-01

Studies

3 studies carry this tag.

Date range

2000 to 2006

Top journals

  • Biochemistry 1
  • Journal of neurochemistry 1
  • Neurobiology of disease 1

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 2006-01-09 Risk genes beyond APOE

    Mutations in human presenilin (PS) genes cause aggressive forms of familial Alzheimer's disease.

  2. Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of disease 2002-02-01 Risk genes beyond APOE

    Buoyant membrane fractions containing presenilin 1 (PS1), an essential component of the gamma-secretase complex, and APP CTFbeta, a gamma-secretase substrate, can be isolated from cultured cells and brain by several different fractionation procedures that are compatible with in vitro gamma-secretase assays.

  3. L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochemistry 2000-08-01 Risk genes beyond APOE

    Progressive cerebral amyloid beta-protein (A beta) deposition is believed to play a central role in the pathogenesis of Alzheimer's disease (AD).

All topic tags with their study counts