dose

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

1. 55/100

   APOE ɛ4 dose associates with increased brain iron and β-amyloid via blood-brain barrier dysfunction

   ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Journal of neurology, neurosurgery, and psychiatry · 2022-04-28 · Brain scans and imaging

   Our results suggest that an increased APOE ɛ4 dose is associated with decreased effective brain-waste clearance, such as iron and β-amyloid, through the BBB.

   • Brain Scans
   • Genetics
   • Brain Biology
2. 47/100

   Sex modifies APOE ε4 dose effect on brain tau deposition in cognitively impaired individuals

   ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain : a journal of neurology · 2021-11-01 · Brain scans and imaging

   Recent studies in cognitively unimpaired elderly individuals suggest that the APOE ε4 allele exerts a dosage-dependent effect on brain tau deposition.

   • Genetics
3. 77/100

   Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer's Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

   ✓ Peer-reviewed alzhub usefulness score 77 out of 100. Journal of Alzheimer's disease : JAD · 2018-01-01 · Brain scans and imaging

   The results are consistent with earlier studies in supporting the hypothesis that LMTM might be effective as monotherapy and that 4 mg twice a day may serve as well as higher doses.

   • Clinical Trials
   • Treatments
   • Brain Scans
4. 71/100

   Population pharmacokinetic and pharmacodynamic analysis of plasma Aβ40 and Aβ42 following single oral doses of the BACE1 inhibitor AZD3839 to healthy volunteers

   ✓ Peer-reviewed alzhub usefulness score 71 out of 100. Clinical pharmacology in drug development · 2014-05-26 · Biomarkers

   Modulating deposition of Aβ-containing plaques in the brain may be beneficial in treating Alzheimer's disease. β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors have been shown to reduce Aβ in plasma and CSF in healthy volunteers.

   • Biomarkers
   • Clinical Trials
   • Brain Biology
5. 36/100

   Is high oral dose L-arginine intake effective in leukoaraiosis? Preliminary data, study protocol and expert's opinion

   ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current aging science · 2013-07-01 · Biomarkers

   Because of its high prevalence in over-65-year-old subjects, we hypothesized that treatment with 6 gr of Larginine, as supplementary dietary option, could be helpful in patients affected by leukoaraiosis to improve the cognitive and gait impairment often observed in these subjects (as demonstrated by the LADIS study).

   • Diagnosis

All topic tags with their study counts