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Home › Research › Topics › discovery

discovery

6 studies tagged discovery, dated 2010-11-25 to 2025-07-15. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging 2025-07-15
  2. Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice 2022-01-01
  3. Blood metabolite markers of neocortical amyloid-β burden: discovery and enrichment using candidate proteins 2016-01-26

Studies

6 studies carry this tag.

Date range

2010 to 2025

Top journals

  • Frontiers in neuroscience 1
  • Journal of proteomics 1
  • Nature medicine 1
  • Neuron 1
  • Translational psychiatry 1

6 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Nature medicine 2025-07-15 Caregiving

    More than 57 million people globally suffer from neurodegenerative diseases, a figure expected to double every 20 years.

  2. Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. mAbs 2022-01-01 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) plays a crucial role in regulating microglial functions and removal of amyloid plaques in Alzheimer's disease (AD).

  3. Blood metabolite markers of neocortical amyloid-β burden: discovery and enrichment using candidate proteins

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Translational psychiatry 2016-01-26 Biomarkers

    We believe this is the first study to investigate associations between blood metabolites and neocortical amyloid burden (NAB) in the search for a blood-based biomarker for Alzheimer's disease (AD).

  4. Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2014-08-14 Tau biomarkers

    A repeat expansion in C9ORF72 causes frontotemporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS).

  5. Discovery and Replication of Gene Influences on Brain Structure Using LASSO Regression

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Frontiers in neuroscience 2012-08-06 Genetics

    We implemented least absolute shrinkage and selection operator (LASSO) regression to evaluate gene effects in genome-wide association studies (GWAS) of brain images, using an MRI-derived temporal lobe volume measure from 729 subjects scanned as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI).

  6. Proteomics of human cerebrospinal fluid: discovery and verification of biomarker candidates in neurodegenerative diseases using quantitative proteomics

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of proteomics 2010-11-25 Genetics

    There is an urgent need for novel biomarkers that can be used to improve the diagnosis, predict the disease progression, improve our understanding of the pathology or serve as therapeutic targets for neurodegenerative diseases.

All topic tags with their study counts