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cascade
4 studies tagged cascade, dated 2005-04-01 to 2021-12-08. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Pyroglutamate Aβ cascade as drug target in Alzheimer's disease 2021-12-08
- Lycopene abrogates Aβ(1-42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer's disease 2015-03-20
- Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade 2006-06-08
Studies
4 studies carry this tag.
Date range
2005 to 2021
Top journals
- Archives of internal medicine 1
- Molecular psychiatry 1
- Neuropharmacology 1
- The Journal of nutritional biochemistry 1
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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One of the central aims in Alzheimer's disease (AD) research is the identification of clinically relevant drug targets.
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The amelioration of Aβ1-42-induced spatial learning and memory impairment by lycopene could be linked, at least in part, to the inhibition of NF-κB activity and the down-regulation of expression of neuroinflammatory cytokines, suggesting that lycopene may be a potential candidate for AD treatment.
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We show here that donepezil, galanathamine and tacrine, therapeutic acetylcholinesterase inhibitors currently being used for treatment of Alzheimer's disease, protect neuronal cells in a time- and concentration-dependent manner from glutamate neurotoxicity that involves apoptosis.
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Use of cholinesterase inhibitors is associated with an increased risk of receiving an anticholinergic drug to manage urinary incontinence.