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av-1451-pet
3 studies tagged av-1451-pet, dated 2016-10-18 to 2021-09-03. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Influence of common reference regions on regional tau patterns in cross-sectional and longitudinal [18F]-AV-1451 PET data 2021-09-03
- Cryptic Sites in Tau Fibrils Explain the Preferential Binding of the AV-1451 PET Tracer toward Alzheimer's Tauopathy 2021-06-21
- [18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation 2016-10-18
Studies
3 studies carry this tag.
Date range
2016 to 2021
Top journals
- ACS chemical neuroscience 1
- Annals of clinical and translational neurology 1
- NeuroImage 1
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Tau PET has allowed for critical insights into in vivo patterns of tau accumulation and change in individuals early in the Alzheimer's disease (AD) continuum.
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In contrast, tau tracer AV-1451 is reported to bind to specific types of tau fibrils (in particular to AD-associated and CTE) with higher binding affinity and only show nonspecific or weaker binding toward tau fibrils dominant with 3R isoforms (associated with PiD).
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The validation of tau radioligands could improve the diagnosis of frontotemporal lobar degeneration and the assessment of disease-modifying therapies.