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antihypertensive-drug
4 studies tagged antihypertensive-drug, dated 2009-02-18 to 2020-08-01. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Repurposing antihypertensive drugs for the prevention of Alzheimer's disease: a Mendelian randomization study 2020-08-01
- Does use of antihypertensive drugs affect the incidence or progression of dementia? A systematic review 2009-10-01
- Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors 2009-09-01
Studies
4 studies carry this tag.
Date range
2009 to 2020
Top journals
- Expert review of neurotherapeutics 1
- International journal of epidemiology 1
- Neurology 1
- The American journal of geriatric pharmacotherapy 1
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Mendelian randomization suggests that lowering systolic blood pressure via the protein targets of antihypertensive drugs is unlikely to affect the risk of developing Alzheimer's disease.
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Sixty-five potentially relevant articles were identified from the 536 publications retrieved by the literature search.
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Our review of cohort studies and clinical trials evaluating antihypertensive drugs in the prevention of cognition decline and all dementia in patients with hypertension indicates that two antihypertensive drug classes have greater protective effects, independent of blood pressure decrease: dihydropyridine calcium-channel blockers as shown in the Syst-Eur trial and angiotensin-AT1 receptor blockers as found in the MOSES and ONTARGET trials.
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Antihypertensive drug use was associated with 8% risk reduction of dementia per year of use for persons < or =75 years.