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1. 43/100

   Amyloid-β peptides act as allosteric modulators of cholinergic signalling through formation of soluble BAβACs

   ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Brain : a journal of neurology · 2015-11-02 · Treatments

   Furthermore, numerous reports indicate that amyloid-β interacts with butyrylcholinesterase and apolipoprotein-E. In the case of butyrylcholinesterase, the results indicated that amyloid-β interacts with a putative activation site at the mouth of its catalytic tunnel, most likely leading to increased acetylcholine influx into the catalytic site, and thereby increasing the intrinsic catalytic rate of butyrylcholinesterase.

   • Brain Biology

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