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acetylcholine-receptor
5 studies tagged acetylcholine-receptor, dated 2004-01-01 to 2012-02-17. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology 2012-02-17
- The allosteric potentiation of nicotinic acetylcholine receptors by galantamine ameliorates the cognitive dysfunction in beta amyloid25-35 i.c.v.-injected mice: involvement of dopaminergic systems 2006-11-29
- Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade 2006-06-08
Studies
5 studies carry this tag.
Date range
2004 to 2012
Top journals
- Neuropharmacology 2
- International journal of molecular sciences 1
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1
- The Journal of pharmacology and experimental therapeutics 1
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Alpha7 nicotinic acetylcholine receptor (α7 nAChR) is an important part of the cholinergic nerve system in the brain.
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Galantamine, a drug for Alzheimer's disease, is a novel cholinergic agent with a dual mode of action, which inhibits acetylcholinesterase and allosterically modulates nicotinic acetylcholine receptors (nAChRs), as a result stimulates catecholamine neurotransmission.
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We show here that donepezil, galanathamine and tacrine, therapeutic acetylcholinesterase inhibitors currently being used for treatment of Alzheimer's disease, protect neuronal cells in a time- and concentration-dependent manner from glutamate neurotoxicity that involves apoptosis.
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The N-methyl-d-aspartate (NMDA) receptor antagonist memantine is an approved drug for treatment of Alzheimer's disease (AD).
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Galantamine is currently used to treat Alzheimer's disease patients; it behaves as a mild blocker of acetylcholinesterase (AChE) and has an allosteric modulating action on nicotinic acetylcholine receptors (nAChRs).