Home › Research › Disease mechanisms
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
John R. Cirrito, Kelvin A. Yamada, Mary Beth Finn, Robert S. Sloviter, Kelly R. Bales, Patrick C. May, Darryle D. Schoepp, Steven M. Paul, Steven J. Mennerick, David M. Holtzman. Neuron, 2005-12-01
Topic: Brain proteins, microglia and lab models
We do not hold a plain-English summary of this study yet. Use the links to the original below for its abstract and findings.
Why it matters
Reports that synaptic activity regulates amyloid-beta levels in brain interstitial fluid in vivo.
How this study scored 56/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 53 of the 95 points we could judge it on, which is 56 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neuron) |
| Journal's citation record | 4 / 4 | Neuron: journal h-index 689 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,267 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 55.1 citations a year over 23 year(s) since 2005 |
| Impact for its field and year | 4 / 6 | Cited 14.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 174 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author David M. Holtzman: h-index 206 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16364896) |
| Free to read | 2 / 2 | Free to read |
| Points | 53 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 53 of the 95 points we could judge it on is 56 out of 100. |
| Total | 56 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 10 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., et al. (2005). Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo. Neuron. https://doi.org/10.1016/j.neuron.2005.10.028
Vancouver
Cirrito JR, Yamada KA, Finn MB, Sloviter RS, Bales KR, May PC, et al. Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo. Neuron. 2005. doi:10.1016/j.neuron.2005.10.028. PMID: 16364896.
BibTeX
@article{cirrito2005-16364896,
author = {Cirrito, John R. and Yamada, Kelvin A. and Finn, Mary Beth and Sloviter, Robert S. and Bales, Kelly R. and May, Patrick C. and Schoepp, Darryle D. and Paul, Steven M. and Mennerick, Steven J. and Holtzman, David M.},
title = {{Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo}},
journal = {Neuron},
year = {2005},
doi = {10.1016/j.neuron.2005.10.028},
pmid = {16364896},
url = {https://doi.org/10.1016/j.neuron.2005.10.028}
}