Relationship between arterial stiffness and cognitive function in elderly subjects with complaints of memory loss

Topic: Brain imaging, connectivity and assessment

Background and purpose To evaluate the relationship between arterial stiffness and cognitive function in a population of elderly subjects reporting memory loss. Methods We studied the association between cognitive function and arterial stiffness in 308 consecutive elderly subjects attending a geriatric outpatient clinic reporting memory impairment. Subjects were classified into 4 categories according to neuropsychological evaluation: normal cognitive function, mild cognitive impairment (MCI), Alzheimer disease (AD), or vascular dementia (VaD). Arterial stiffness was evaluated by carotid-femoral pulse wave velocity (PWV) measurement using Complior. Results In this population, 78+/-8 years of age (women 64%), AD was present in 41%, VaD in 6%, MCI in 27%, and 26% of subjects had normal cognitive function. After adjustment for age, gender, systolic blood pressure, education level, cardiovascular diseases, and antihypertensive therapy, a significant association was observed between PWV and cognitive status (P<0.0001). PWV appears significantly higher in subjects with VaD (15.2+/-3.9 m/s) or AD (13.3+/-2.9 m/s) than in those without cognitive impairment (11.5+/-2.0 m/s; P<0.001). Moreover, PWV was higher in subjects with MCI (12.6+/-2.6 m/s) than in those without cognitive impairment (11.5+/-2.0 m/s; P=0.01). For each 2 m/s increment in PWV, the adjusted odds ratio (95% CI) was 1.73 (1.27 to 2.47) for AD and 3.52 (1.87 to 8.05) for VaD. Conclusions Our results showed a relationship between arterial stiffness and cognitive impairment, suggesting that functional changes of the arterial system could be involved in the onset of dementia (VaD or AD types).

Key findings

• Results In this population, 78+/-8 years of age (women 64%), AD was present in 41%, VaD in 6%, MCI in 27%, and 26% of subjects had normal cognitive function.
• After adjustment for age, gender, systolic blood pressure, education level, cardiovascular diseases, and antihypertensive therapy, a significant association was observed between PWV and cognitive status (P<0.0001).
• PWV appears significantly higher in subjects with VaD (15.2+/-3.9 m/s) or AD (13.3+/-2.9 m/s) than in those without cognitive impairment (11.5+/-2.0 m/s; P<0.001).
• Conclusions Our results showed a relationship between arterial stiffness and cognitive impairment, suggesting that functional changes of the arterial system could be involved in the onset of dementia (VaD or AD types).

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Study details

• Evidence strengthLow

Read the original

• DOI: 10.1161/01.str.0000181771.82518.1c
• PubMed: 16151027
• Original source →

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@article{hanon2005-16151027,
  author  = {Hanon, O. and Haulon, S. and Lenoir, H. and Seux, M. L. and Rigaud, A. S. and Safar, M. and Girerd, X. and Forette, F.},
  title   = {{Relationship between arterial stiffness and cognitive function in elderly subjects with complaints of memory loss}},
  journal = {Stroke},
  year    = {2005},
  doi     = {10.1161/01.str.0000181771.82518.1c},
  pmid    = {16151027},
  url     = {https://doi.org/10.1161/01.str.0000181771.82518.1c}
}

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