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33/100

✓ Peer-reviewed alzhub usefulness score 33 out of 100. Risk genes beyond APOE

Topic: Amyloid, tau and blood-test diagnosis

The most notable effect sizes were observed in entropy for Beta1 and Beta3 bands in frontal regions for the DTS7 and DTS1 tasks, Beta2 relative power in C4 during DTAN, Theta modulation in the Theta and alpha-1 bands in frontal regions during DTS7, and Alpha2 modulations in the same task. The proposed experiment effectively extracted brain information that differentiates between carriers and non-carriers of the PSEN1-E280A variant. DTC values in the alpha band (frontal and central regions) and the beta band (central regions) exhibited larger effect sizes, suggesting that these areas are sensitive to preclinical cognitive and motor differences. The experimental paradigm and data-processing pipeline ensured the acquisition of EEG data with meaningful neurological information. This combination of novel biomarkers enhances non-invasive and portable tools for identifying ADAD carriers during preclinical stages.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Rada, J. M., Saldarriaga, L. M. Z., Garcia‐Cifuentes, E., Niño, D. F. A., Hidalgo, M. J., Guerrero, A., et al. (2025). Quantitative EEG obtained from Dual‐Task paradigms for the study of preclinical populations at risk of Alzheimer Disease. Alzheimer s & Dementia. https://doi.org/10.1002/alz70856_103932

Vancouver

Rada JM, Saldarriaga LMZ, Garcia‐Cifuentes E, Niño DFA, Hidalgo MJ, Guerrero A, et al. Quantitative EEG obtained from Dual‐Task paradigms for the study of preclinical populations at risk of Alzheimer Disease. Alzheimer s & Dementia. 2025. doi:10.1002/alz70856_103932. PMID: 41443245.

BibTeX

@article{rada2025-41443245,
  author  = {Rada, Juliana Moreno and Saldarriaga, Luisa María Zapata and Garcia‐Cifuentes, Elkin and Niño, David Fernando Aguillón and Hidalgo, María José and Guerrero, Alejandro and Ochoa-Gómez, John Fredy},
  title   = {{Quantitative EEG obtained from Dual‐Task paradigms for the study of preclinical populations at risk of Alzheimer Disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_103932},
  pmid    = {41443245},
  url     = {https://doi.org/10.1002/alz70856_103932}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

The most notable effect sizes were observed in entropy for Beta1 and Beta3 bands in frontal regions for the DTS7 and DTS1 tasks, Beta2 relative power in C4 during DTAN, Theta modulation in the Theta and alpha-1 bands in frontal regions during DTS7, and Alpha2 modulations in the same task.
The proposed experiment effectively extracted brain information that differentiates between carriers and non-carriers of the PSEN1-E280A variant.
DTC values in the alpha band (frontal and central regions) and the beta band (central regions) exhibited larger effect sizes, suggesting that these areas are sensitive to preclinical cognitive and motor differences.
The experimental paradigm and data-processing pipeline ensured the acquisition of EEG data with meaningful neurological information.
This combination of novel biomarkers enhances non-invasive and portable tools for identifying ADAD carriers during preclinical stages.

Why it matters

Using quantitative EEG during dual-task paradigms, this study found brain signal differences between carriers and non-carriers of the PSEN1-E280A variant in preclinical stages. It suggests these measures could enhance non-invasive tools for identifying carriers, but it does not test any treatment, cure or prevention.

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Study details

Participants37
Evidence strengthLow

How this study scored 33/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	37 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 3 year(s) since 2025
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author John Fredy Ochoa-Gómez: h-index 12 (OpenAlex, whole career)
Institution's track record	0 / 3	Universidad de Antioquia: institution h-index 298 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41443245)
Free to read	2 / 2	Free to read
Total	33 / 100	—

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