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Notch signaling and ageing
Polychronidou E, Vlachakis D, Vlamos P, Baumann M, Kossida S.. Advances in experimental medicine and biology, 2015-01-01
Topic: Brain proteins, microglia and lab models
Notch signaling is a master controller of the neural stem cell and neural development maintaining a significant role in the normal brain function. Notch genes are involved in embryogenesis, nervous system, and cardiovascular and endocrine function. On the other side, there are studies representing the involvement of Notch mutations in sporadic Alzheimer disease, other neurodegenerative diseases such as Down syndrome, Pick's and Prion's disease, and CADASIL. This manuscript attempts to present a holistic view of the positive or negative contribution of Notch signaling in the adult brain, and at the same time to present and promote the promising research fields of study.
Key findings
- Notch signaling is a master controller of the neural stem cell and neural development maintaining a significant role in the normal brain function.
Why it matters
This review discusses the role of Notch signaling in normal brain function and its possible involvement in sporadic Alzheimer's disease and other neurodegenerative diseases including Down syndrome. It presents a research perspective and does not test any treatment, cure, or prevention.
Study details
- Evidence strengthLow
How this study scored 32/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, so that was left out: it earned 31 of the 96 points we could judge it on, which is 32 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Advances in experimental medicine and biology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 27 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.1 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 2 / 6 | Cited 1.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Σοφία Κοσσίδα: h-index 27 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Biomedical Research Foundation of the Academy of Athens: institution h-index 221 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 25416974) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 31 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 31 of the 96 points we could judge it on is 32 out of 100. |
| Total | 32 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Polychronidou, E., Vlachakis, D., Vlamos, P., Baumann, M., & Kossida, S. (2015). Notch signaling and ageing. Advances in experimental medicine and biology. https://doi.org/10.1007/978-3-319-08927-0_6
Vancouver
Polychronidou E, Vlachakis D, Vlamos P, Baumann M, Kossida S. Notch signaling and ageing. Advances in experimental medicine and biology. 2015. doi:10.1007/978-3-319-08927-0_6. PMID: 25416974.
BibTeX
@article{polychronidou2015-25416974,
author = {Polychronidou, E. and Vlachakis, D. and Vlamos, P. and Baumann, M. and Kossida, S.},
title = {{Notch signaling and ageing}},
journal = {Advances in experimental medicine and biology},
year = {2015},
doi = {10.1007/978-3-319-08927-0_6},
pmid = {25416974},
url = {https://doi.org/10.1007/978-3-319-08927-0_6}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
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