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Localized surface plasmon resonance biosensors
Zhao J, Zhang X, Yonzon CR, Haes AJ, Van Duyne RP.. Nanomedicine (London, England), 2006-08-01
Topic: Brain proteins, microglia and lab models
In this review, the most recent progress in the development of noble metal nano-optical sensors based on localized surface plasmon resonance (LSPR) spectroscopy is summarized. The sensing principle relies on the LSPR spectral shifts caused by the surrounding dielectric environmental change in a binding event. Nanosphere lithography, an inexpensive and simple nanofabrication technique, has been used to fabricate the nanoparticles as the LSPR sensing platforms. As an example of the biosensing applications, the LSPR detection for a biomarker of Alzheimer's disease, amyloid-derived diffusable ligands, in human brain extract and cerebrospinal fluid samples is highlighted. Furthermore, the LSPR sensing method can be modified easily and used in a variety of applications. More specifically, a LSPR chip capable of multiplex sensing, a combined electrochemical and LSPR protocol and a fabrication method of solution-phase nanotriangles are presented here.
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APA 7th
Zhao, J., Zhang, X., Yonzon, C. R., Haes, A. J., & Van Duyne, R. P. (2006). Localized surface plasmon resonance biosensors. Nanomedicine (London, England). https://doi.org/10.2217/17435889.1.2.219
Vancouver
Zhao J, Zhang X, Yonzon CR, Haes AJ, Van Duyne RP. Localized surface plasmon resonance biosensors. Nanomedicine (London, England). 2006. doi:10.2217/17435889.1.2.219. PMID: 17716111.
BibTeX
@article{zhao2006-17716111,
author = {Zhao, J. and Zhang, X. and Yonzon, C. R. and Haes, A. J. and Van Duyne, R. P.},
title = {{Localized surface plasmon resonance biosensors}},
journal = {Nanomedicine (London, England)},
year = {2006},
doi = {10.2217/17435889.1.2.219},
pmid = {17716111},
url = {https://doi.org/10.2217/17435889.1.2.219}
}
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Key findings
- The sensing principle relies on the LSPR spectral shifts caused by the surrounding dielectric environmental change in a binding event.
- Nanosphere lithography, an inexpensive and simple nanofabrication technique, has been used to fabricate the nanoparticles as the LSPR sensing platforms.
- As an example of the biosensing applications, the LSPR detection for a biomarker of Alzheimer's disease, amyloid-derived diffusable ligands, in human brain extract and cerebrospinal fluid samples is highlighted.
- Furthermore, the LSPR sensing method can be modified easily and used in a variety of applications.
- More specifically, a LSPR chip capable of multiplex sensing, a combined electrochemical and LSPR protocol and a fabrication method of solution-phase nanotriangles are presented here.
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Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 21 of the 58 points we could judge it on, which is 36 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Nanomedicine (London, England)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17716111) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 21 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 21 of the 58 points we could judge it on is 36 out of 100. |
| Total | 36 / 100 | — |
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