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Classification of tauopathies from human brain homogenates through salt‐modulated tau amplification
Alessia Santambrogio, Michael A. Metrick, Pu Xu, Nicholas C. T. Gallagher, Shunsuke Koga, Bernardino Francesco Ghetti, Dennis W. Dickson, Byron W. Caughey et al.. Alzheimer s & Dementia, 2026-02-01
Topic: Brain proteins, microglia and lab models
This method differentiated eight tauopathies, including Alzheimer's disease, Pick disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), argyrophilic grain disease (AGD), frontotemporal dementia with parkinsonism associated with chromosome 17 with N279K mutation (FTDP-17 N279K), and globular glial tauopathies types II and III. Subclassification of 4R tauopathies was achieved by modulating salt conditions and analyzing aggregation profiles. FTIR confirmed preservation of conformational differences. This salt-modulated, heparin-free RT-QuIC platform enables sensitive tauopathy classification based on strain-specific kinetics and structure. It offers a practical tool for diagnostic development, mechanistic studies, and therapeutic screening.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Santambrogio, A., Metrick, M. A., Xu, P., Gallagher, N. C. T., Koga, S., Ghetti, B. F., et al. (2026). Classification of tauopathies from human brain homogenates through salt‐modulated tau amplification. Alzheimer s & Dementia. https://doi.org/10.1002/alz.71112
Vancouver
Santambrogio A, Metrick MA, Xu P, Gallagher NCT, Koga S, Ghetti BF, et al. Classification of tauopathies from human brain homogenates through salt‐modulated tau amplification. Alzheimer s & Dementia. 2026. doi:10.1002/alz.71112. PMID: 41685551.
BibTeX
@article{santambrogio2026-41685551,
author = {Santambrogio, Alessia and Metrick, Michael A. and Xu, Pu and Gallagher, Nicholas C. T. and Koga, Shunsuke and Ghetti, Bernardino Francesco and Dickson, Dennis W. and Caughey, Byron W. and others},
title = {{Classification of tauopathies from human brain homogenates through salt‐modulated tau amplification}},
journal = {Alzheimer s \& Dementia},
year = {2026},
doi = {10.1002/alz.71112},
pmid = {41685551},
url = {https://doi.org/10.1002/alz.71112}
}
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Key findings
- This method differentiated eight tauopathies, including Alzheimer's disease, Pick disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), argyrophilic grain disease (AGD), frontotemporal dementia with parkinsonism associated with chromosome 17 with N279K mutation (FTDP-17 N279K), and globular glial tauopathies types II and III.
- Subclassification of 4R tauopathies was achieved by modulating salt conditions and analyzing aggregation profiles.
- FTIR confirmed preservation of conformational differences.
- This salt-modulated, heparin-free RT-QuIC platform enables sensitive tauopathy classification based on strain-specific kinetics and structure.
- It offers a practical tool for diagnostic development, mechanistic studies, and therapeutic screening.
Why it matters
A salt-modulated, heparin-free RT-QuIC method distinguished eight tauopathies, including Alzheimer's disease, based on strain-specific aggregation kinetics and structure. This is a laboratory diagnostic tool, not a treatment, cure or prevention.
Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 4 / 6 | Cited 8.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Michele Vendruscolo: h-index 118 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Cambridge: institution h-index 1,973 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41685551) |
| Free to read | 2 / 2 | Free to read |
| Total | 43 / 100 | — |
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