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Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB
Liu Q, Chen Y, Shen C, Xiao Y, Wang Y, Liu Z, Liu X.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016-12-21
Topic: Brain proteins, microglia and lab models
Chicoric acid (CA), a natural phenolic acid extracted from chicory and the echinacea (purple coneflower) plant ( Echinacea purpurea ), has been regarded as a nutraceutical that has powerful antioxidant and antiobesity activities. We investigated the inhibitory effects of CA on systemic inflammation-induced neuroinflammation, amyloidogenesis, and cognitive impairment. C57BL/6J mice were treated with 0.05% CA in the drinking water for 45 d.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Liu, Q., Chen, Y., Shen, C., Xiao, Y., Wang, Y., Liu, Z., et al. (2017). Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. https://doi.org/10.1096/fj.201601071r
Vancouver
Liu Q, Chen Y, Shen C, Xiao Y, Wang Y, Liu Z, et al. Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017. doi:10.1096/fj.201601071r. PMID: 28003341.
BibTeX
@article{liu2017-28003341,
author = {Liu, Q. and Chen, Y. and Shen, C. and Xiao, Y. and Wang, Y. and Liu, Z. and Liu, X.},
title = {{Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB}},
journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
year = {2017},
doi = {10.1096/fj.201601071r},
pmid = {28003341},
url = {https://doi.org/10.1096/fj.201601071r}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- We investigated the inhibitory effects of CA on systemic inflammation-induced neuroinflammation, amyloidogenesis, and cognitive impairment.
- C57BL/6J mice were treated with 0.05% CA in the drinking water for 45 d.
- The mice were then treated by intraperitoneal injection of lipopolysaccharide (LPS).
- It was found that CA prevented LPS-induced memory impairment and neuronal loss through behavioral tests and histological examination.
Why it matters
In mice, chicoric acid given in drinking water prevented memory impairment and neuronal loss caused by an injected inflammatory trigger. This is early animal work and does not establish that chicoric acid helps patients.
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Study details
- Effect size0.05%
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (FASEB journal : official publication of the Federation of American Societies for Experimental Biology) |
| Journal's citation record | 3 / 4 | The FASEB Journal: journal h-index 401 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 147 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 13.4 citations a year over 11 year(s) since 2017 |
| Impact for its field and year | 3 / 6 | Cited 5.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 38 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Xuebo Liu: h-index 84 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Northwest A&F University: institution h-index 447 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28003341) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 43 / 100 | — |
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