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41/100

✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain scans and imaging

Topic: Brain proteins, microglia and lab models

In both cohorts there were significant associations between CSF MTBR-tau243 and the temporal meta-ROI (BioFINDER-2: t = 17.1, p < 0.001, Knight-ADRC: t=11.0, p <0.001). This association was not different by sex (BioFINDER-2: t = 0.54, p = 0.6, Knight-ADRC: t=0.1, p = 0.9) (Figure 1). This finding remained consistent within the Aβ-positive subsets of both cohorts (Figure 2). Across two cohorts we found that sex did not moderate the relationship between tau-PET and CSF MTBR-tau243, two distinct markers of aggregated tau pathology. This suggests the sex effects found in tau-PET likely represent a true biological finding not specifically tied to tau-PET methodology.

Key findings

In both cohorts there were significant associations between CSF MTBR-tau243 and the temporal meta-ROI (BioFINDER-2: t = 17.1, p < 0.001, Knight-ADRC: t=11.0, p <0.001).
This association was not different by sex (BioFINDER-2: t = 0.54, p = 0.6, Knight-ADRC: t=0.1, p = 0.9) (Figure 1).
This finding remained consistent within the Aβ-positive subsets of both cohorts (Figure 2).
Across two cohorts we found that sex did not moderate the relationship between tau-PET and CSF MTBR-tau243, two distinct markers of aggregated tau pathology.
This suggests the sex effects found in tau-PET likely represent a true biological finding not specifically tied to tau-PET methodology.

Why it matters

This study found that the relationship between tau PET and a spinal fluid marker of tau did not differ by sex across two cohorts. It is an observational biomarker study and does not test any treatment, cure, or prevention.

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Study details

Study designcross-sectional
Evidence strengthModerate

How this study scored 41/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 3 year(s) since 2025
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Rik Ossenkoppele: h-index 84 (OpenAlex, whole career)
Institution's track record	2 / 3	Washington University in St. Louis: institution h-index 1,962 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 8 institution(s) in 4 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41443270)
Free to read	2 / 2	Free to read
Total	41 / 100	—

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Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Robinson, C. G., Binette, A. P., Horie, K., Sato, C., Schindler, S. E., Barthélemy, N. R., et al. (2025). Associations between tau PET and CSF MTBR243 do not vary by sex. Alzheimer s & Dementia. https://doi.org/10.1002/alz70856_098213

Vancouver

Robinson CG, Binette AP, Horie K, Sato C, Schindler SE, Barthélemy NR, et al. Associations between tau PET and CSF MTBR243 do not vary by sex. Alzheimer s & Dementia. 2025. doi:10.1002/alz70856_098213. PMID: 41443270.

BibTeX

@article{robinson2025-41443270,
  author  = {Robinson, Carling G. and Binette, Alexa Pichet and Horie, Kanta and Sato, Chihiro and Schindler, Suzanne Elizabeth and Barthélemy, Nicolas R. and Bateman, Randall John and Benzinger, Tammie L.S. and others},
  title   = {{Associations between tau PET and CSF MTBR243 do not vary by sex}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_098213},
  pmid    = {41443270},
  url     = {https://doi.org/10.1002/alz70856_098213}
}

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