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199 results for "antipsychotic".
Guides and answers on this site
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Antipsychotics for dementia agitationPage
Support · alzhub.org/caregiving/antipsychotics
Antipsychotics for agitation in dementia: are they safe? They can reduce agitation and aggression a little, but they carry real risks, including a higher risk of death, stroke and pneumonia. The studies support trying other …
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Caregiving evidence: what actually helps dementia caregiversPage
Main · alzhub.org/caregiving
… stays and delirium Antipsychotics for agitation in dementia How to read the labels: Measured counted, surveyed or written in law. Modelled estimate produced by a statistical model — an estimate, not a count. Basis not stated …
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Agitation in dementia: the studiesPage
Research · alzhub.org/answers/agitation-in-dementia
… training) and medicines (antipsychotics, antidepressants, and newer drugs approved specifically for agitation), and weigh the modest benefits of the drugs against their risks in older people. This page describes what published …
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Is there anything for agitation and aggression?Question
Questions and answers · Treatment · alzhub.org/faq#agitation-medication
… Brexpiprazole is an atypical antipsychotic, and Facts and Figures 2026 notes that this class “has been associated with an increased risk of stroke and death in older people with dementia-related psychosis,” adding that “non-drug …
All 19 guides and answers that match →
Research summaries 180
Showing 1–10, page 1 of 18. Filter these by subject, year and score in the research library →
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Variation in use of antipsychotic medications in nursing homes in the United States: A systematic reviewResearch summary
Research summaries · alzhub.org/study/variation-in-use-of-antipsychotic-medications-in-nursing-homes-in-the-28122506
Background The use of antipsychotic medications (APMs) in nursing home residents in the U.S. is an increasingly prominent issue and has been associated with increased risk of hospitalization, cardiovascular events, hip fractures, …
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Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trialsResearch summary
Research summaries · alzhub.org/study/risk-of-death-with-atypical-antipsychotic-drug-treatment-for-dementia-16234500
Context Atypical antipsychotic medications are widely used to treat delusions, aggression, and agitation in people with Alzheimer disease and other dementia; however, concerns have arisen about the increased risk for …
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ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementiaResearch summary
Research summaries · alzhub.org/study/acnp-white-paper-update-on-use-of-antipsychotic-drugs-in-elderly-17637610
In elderly persons, antipsychotic drugs are clinically prescribed off-label for a number of disorders outside of their Food and Drug Administration (FDA)-approved indications (schizophrenia and bipolar disorder). The largest …
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Research summaries · alzhub.org/study/assessment-of-reported-comparative-effectiveness-and-safety-of-30901041
Importance Atypical antipsychotics offer modest effectiveness compared with placebo but with serious safety risks, including a boxed warning for the risk of death in the treatment of behavioral and psychological symptoms of …
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Multiple adverse outcomes associated with antipsychotic use in people with dementia: population based matched cohort studyResearch summary
Research summaries · alzhub.org/study/multiple-adverse-outcomes-associated-with-antipsychotic-use-in-people-38631737
… associated with use of antipsychotics in people with dementia. Design Population based matched cohort study. Setting Linked primary care, hospital and mortality data from Clinical Practice Research Datalink (CPRD), England. …
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Geographic Variation of Antidementia and Antipsychotic Medication Use Among US Nursing Home Residents With DementiaResearch summary
Research summaries · alzhub.org/study/geographic-variation-of-antidementia-and-antipsychotic-medication-use-38833712
memantine, cholinesterase inhibitor (ChEI), antipsychotic use] estimated adjusted odds ratios (aOR) and 95% CIs for resident, facility, and HRR characteristics. We then fit a series of cross-classified multilevel logistic models …
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Benzodiazepine or Antipsychotic Use and Mortality Risk Among Patients With Dementia in Hospice CareResearch summary
Research summaries · alzhub.org/study/benzodiazepine-or-antipsychotic-use-and-mortality-risk-among-patients-41085983
… cohort and 10 240 in the antipsychotic cohort. Initiation of benzodiazepine use was associated with higher 180-day mortality compared with nonuse (HR, 1.41; 95% CI, 1.38-1.44), as was initiation of antipsychotic use (HR, 1.16; …
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Antipsychotics for deliriumResearch summary
Research summaries · alzhub.org/study/antipsychotics-for-delirium-17443602
… haloperidol, a typical antipsychotic that may cause adverse extrapyramidal symptoms among patients, may be replaced by atypical antipsychotics such as risperidone, olanzapine or quetiapine, that are as effective as haloperidol in …
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Research summaries · alzhub.org/study/antipsychotic-prescriptions-in-people-with-dementia-in-primary-care-a-40967729
… individuals with no antipsychotic prescription between the ages of 60 and 85 years between 2000 and 2023, a previous history of antipsychotics, missing deprivation information, or only one eligible prescription). We included 9819 …
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Clinical outcomes after antipsychotic discontinuation in nursing home residents with dementia: a nationwide cohort studyResearch summary
Research summaries · alzhub.org/study/clinical-outcomes-after-antipsychotic-discontinuation-in-nursing-home-42410659
Background Antipsychotic medications in people with dementia should be avoided or limited to treatment courses of fewer than 3-4 months. It is unknown whether discontinuation of long-term antipsychotic medications in this …
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