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315 results for "driving".

Research summaries 292

Showing the best 200 of 292, 81–90, page 9 of 20. Filter these by subject, year and score in the research library →

1. Making the final cut: pathogenic amyloid-β peptide generation by γ-secretaseResearch summary

   Research summaries · alzhub.org/study/making-the-final-cut-pathogenic-amyloid-peptide-generation-by-31225454

   … side also been a major driving force for structural and in depth mechanistic studies on this key AD drug target in the past few years. Cell stress 2018 genetics_genes Steiner H, Fukumori A, Tagami S, Okochi M.

2. Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer's diseaseResearch summary

   Research summaries · alzhub.org/study/multi-tissue-neocortical-transcriptome-wide-association-study-33947463

   … common genetic variants driving differences in transcript expression that confer AD risk is necessary to elucidate AD mechanism and develop therapeutic interventions. We modify the FUSION transcriptome-wide association study …

3. Post-diagnostic support in Australia: Perspectives of people recently diagnosed with dementia and their carersResearch summary

   Research summaries · alzhub.org/study/post-diagnostic-support-in-australia-perspectives-of-people-recently-40223560

   … support; Support with driving concerns; Engaging and tailored information. Perspectives of people recently diagnosed with dementia and their carers identified the need to ensure that post-diagnostic support addressed their …

4. Replacement of leisure-time sedentary behavior with various physical activities and the risk of dementia incidence and mortality: A prospective cohort studyResearch summary

   Research summaries · alzhub.org/study/replacement-of-leisure-time-sedentary-behavior-with-various-physical-36379419

   … TV, computer use, and driving) and PA (walking for pleasure, light and heavy do-it-yourself activity, strenuous sports, and other exercise) frequency and duration in the 4 weeks prior to evaluation. Journal of sport and health …

5. Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseasesResearch summary

   Research summaries · alzhub.org/study/role-of-nlrp3-inflammasome-mediated-neuronal-pyroptosis-and-37725102

   … explore the mechanisms driving NLRP3 activation and assembly, as well as the post-translational modifications regulating NLRP3 inflammasome activation. Understanding these mechanisms will contribute to a deeper understanding of …

6. Structural and social determinants of dementia risk among adults racialized as Black: Results from a community‐based system dynamics approachResearch summary

   Research summaries · alzhub.org/study/structural-and-social-determinants-of-dementia-risk-among-adults-40684246

   … and mental healthcare, driving dementia risk. Those from more deprived areas highlighted the need for improved health education, public transportation, healthcare access, and job opportunities. Addressing dementia disparities …

7. Tau Pathology Drives Disease‐Associated Astrocyte Reactivity in Salt‐Induced NeurodegenerationResearch summary

   Research summaries · alzhub.org/study/tau-pathology-drives-diseaseassociated-astrocyte-reactivity-in-39853966

   … pathology and A1R signaling, driving DAA-like astrocyte reactivity. Targeting the Tau-A1R axis may provide a novel therapeutic strategy for reducing HSD-induced neuroinflammation and cognitive deficits. In mice on a high-salt …

8. Alzheimer disease: Amyloid peptide controversies and challenges of anti-Aβ immunotherapyResearch summary

   Research summaries · alzhub.org/study/alzheimer-disease-amyloid-peptide-controversies-and-challenges-of-40674941

   … receptor activation and driving Alzheimer disease neuropathology, emphasizing that early-stage Aβ-targeted immunotherapy may prevent cognitive decline while preserving the neuroprotective functions of Aβ, thereby refining …

9. ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s diseaseResearch summary

   Research summaries · alzhub.org/study/apoe-calypse-tau-apoetau-synergy-in-alzheimers-disease-40856646

   … molecular mechanisms driving AD and primary tauopathies. This review summarizes evidence that APOE ε4 worsens tau-mediated neurodegeneration and tau-related pathology, in addition to promoting amyloid deposition. It suggests the …

10. Epidemiology of dementias and Alzheimer's diseaseResearch summary

    Research summaries · alzhub.org/study/epidemiology-of-dementias-and-alzheimer-s-disease-23159715

    … consequences. It is driving the current epidemic of dementia, both in terms of its extent and global distribution. The aim of the study was to summarize recent findings relevant to the epidemiological knowledge of dementia and …

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