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315 results for "driving".
Research summaries 292
Showing the best 200 of 292, 51–60, page 6 of 20. Filter these by subject, year and score in the research library →
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Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleepResearch summary
Research summaries · alzhub.org/study/norepinephrine-mediated-slow-vasomotion-drives-glymphatic-clearance-39788123
… vasomotion acts as a pump driving CSF into the brain. On the contrary, the sleep aid zolpidem suppressed norepinephrine oscillations and glymphatic flow, highlighting the critical role of norepinephrine-driven vascular dynamics …
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Alzheimer and vascular dementias and driving. A prospective road and laboratory studyResearch summary
Research summaries · alzhub.org/study/alzheimer-and-vascular-dementias-and-driving-a-prospective-road-and-7715061
Objective To characterize on-the-road, behind-the-wheel driving abilities and related laboratory performances of subjects with mild Alzheimer's disease (AD) and vascular dementia. Design Prospective, experimental study involving …
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Environmental predictors of objectively measured out-of-home time among older adults with cognitive declineResearch summary
Research summaries · alzhub.org/study/environmental-predictors-of-objectively-measured-out-of-home-time-30878823
… (gender, age, education, driving status, fear of falling) were examined as potential predictors. After adjusting main effects of allocation group, time of measures, and their interactive effect, a mixed model showed that younger …
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Single-cell RNA sequencing-derived signatures define response patterns to atezolizumab + bevacizumab in advanced hepatocellular carcinomaResearch summary
Research summaries · alzhub.org/study/single-cell-rna-sequencing-derived-signatures-define-response-39709141
… underlying cellular processes driving clinical benefit vs. resistance to atezo+bev. Methods We harnessed the power of single-cell RNA sequencing in advanced HCC to derive gene expression signatures recapitulating 21 cell …
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In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesisResearch summary
Research summaries · alzhub.org/study/in-vivo-and-in-vitro-evidence-supporting-a-role-for-the-inflammatory-8892349
Interleukin-1 (IL-1), an inflammatory cytokine overexpressed in the neuritic plaques of Alzheimer's disease, activates astrocytes and enhances production and processing of beta-amyloid precursor protein (beta-APP). Activated …
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Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer's diseaseResearch summary
Research summaries · alzhub.org/study/innate-immune-sensing-of-z-nucleic-acids-by-zbp1-ripk1-axis-drives-40902587
… amplified in AD microglia, driving innate immune responses and neuroinflammation through sensing Z-form mitochondrial DNA (mtDNA). We show that oxidized mtDNA, generated by amyloid-β (Aβ)-induced oxidative stress, was fragmented …
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The effects of driving cessation on the elderly with dementia and their caregiversResearch summary
Research summaries · alzhub.org/study/the-effects-of-driving-cessation-on-the-elderly-with-dementia-and-11426682
This research explores how the loss of driving privileges by impaired drivers affects households. The particular focus is on the travel behavior and preceptions of people living in households where an elderly driver has had his …
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Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancerResearch summary
Research summaries · alzhub.org/study/apolipoprotein-e-induces-pathogenic-senescent-like-myeloid-cells-in-36868226
… subset of myeloid cells driving immune suppression, tumor proliferation, and treatment resistance. Physiologically, neutrophils are known to have a short half-life. Here, we report the identification of a subset of neutrophils …
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omicSynth: An open multi-omic community resource for identifying druggable targets across neurodegenerative diseasesResearch summary
Research summaries · alzhub.org/study/omicsynth-an-open-multi-omic-community-resource-for-identifying-38181731
… biological mechanisms in driving discovery and creating disease modifying therapies. The global population is aging, driving an urgent need for therapeutics that stop disease progression and eliminate symptoms. In this study, we …
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Dementia and caregiver burden: A three-year longitudinal studyResearch summary
Research summaries · alzhub.org/study/dementia-and-caregiver-burden-a-three-year-longitudinal-study-31821606
… medications, lack of driving ability-and female sex of caregivers were associated with greater burden. Conclusions High levels of caregiver burden are present in a large proportion of caregivers of people with dementia and this …
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