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315 results for "driving".

Research summaries 292

Showing the best 200 of 292, 191–200, page 20 of 20. Filter these by subject, year and score in the research library →

1. Regional multimodal relationships between tau, hypometabolism, atrophy, and fractional anisotropy in atypical Alzheimer's diseaseResearch summary

   Research summaries · alzhub.org/study/regional-multimodal-relationships-between-tau-hypometabolism-atrophy-30549156

   … view that tau is the driving force behind neurodegeneration in atypical AD, and that a breakdown in structural connectivity is related to cortical neurodegeneration, particularly hypometabolism. Tau in frontal and parietal …

2. Secular trends in cognitive trajectories of diverse older adultsResearch summary

   Research summaries · alzhub.org/study/secular-trends-in-cognitive-trajectories-of-diverse-older-adults-31672483

   … part of the mechanisms driving secular trends in cognitive aging and dementia. Later birth year was associated with higher initial cognitive levels for Whites and Blacks, but not Hispanics. Later birth year was also associated …

3. APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloidResearch summary

   Research summaries · alzhub.org/study/apoe4-exacerbates-synuclein-pathology-and-related-toxicity-32024798

   … Alzheimer's disease mainly by driving amyloid-β pathology. Recently, APOE4 has also been found to be a genetic risk factor for Lewy body dementia (LBD), which includes dementia with Lewy bodies and Parkinson's disease dementia. …

4. Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathyResearch summary

   Research summaries · alzhub.org/study/aberrant-deposition-of-stress-granule-resident-proteins-linked-to-30767771

   … key disease mechanism driving TDP-43 proteinopathy in c9FTD/ALS. Results Relative to control mice, gliosis and neurodegeneration accompanied by cognitive and motor deficits were observed in (G 4 C 2 ) 149 mice by 6 months of …

5. Alzheimer Disease: Scientific Breakthroughs and Translational ChallengesResearch summary

   Research summaries · alzhub.org/study/alzheimer-disease-scientific-breakthroughs-and-translational-28578785

   … pathology, the latter driving cognitive deficits and dementia severity. Structural and molecular imaging can now recapitulate the neuropathology of AD antemortem. Autosomal dominant forms of early-onset familial AD gave rise to …

6. Metabolic Syndrome and the Cellular Phase of Alzheimer's DiseaseResearch summary

   Research summaries · alzhub.org/study/metabolic-syndrome-and-the-cellular-phase-of-alzheimer-s-disease-28253987

   … play critical roles in driving neuroinflammation, an important cause of AD pathogenesis. Studies of MetS and AD have traditionally remained in distinct domains. The cross talk between MetS and the cellular phase of AD is an …

7. Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health DataResearch summary

   Research summaries · alzhub.org/study/methodology-for-establishing-a-community-wide-life-laboratory-for-30102277

   … wearable actigraphs. Driving sensors are also installed in participants' cars and computer (PC, tablet or smartphone) use is tracked. Data is annotated via frequent online self-report options that provide vital information with …

8. Spatiotemporal trends in dementia‐associated deaths, what do the data reveal?Research summary

   Research summaries · alzhub.org/study/spatiotemporal-trends-in-dementiaassociated-deaths-what-do-the-data-f5b40125

   … cause of death coding, driving the progressively increasing temporal trend in relative risk of dementia‐associated death. These factors could be a combination of increased dementia awareness, a larger proportion of people being …

9. Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brainResearch summary

   Research summaries · alzhub.org/study/tau-covariance-patterns-in-alzheimer-s-disease-patients-match-31077982

   … through neural networks, driving neurodegeneration We found a striking convergence between [ 18 F]flortaucipir covariance patterns and intrinsic connectivity maps (range Spearman rho's: 0.32–0.78, p < .001), which corresponded …

10. There has been an awakening: Emerging mechanisms of C9orf72 mutations in FTD/ALSResearch summary

    Research summaries · alzhub.org/study/there-has-been-an-awakening-emerging-mechanisms-of-c9orf72-mutations-27059391

    … are most important for driving disease and therefore most critical for considering during the development of therapeutic interventions. This article is part of a Special Issue entitled SI:RNA Metabolism in Disease. Three major …

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