36/100
Study design descriptive correlational design. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research
28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
Predictors of patient wishes and influence of family and clinicians are discussed. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
This article explores how married couples managed their finances and made financial decisions when one spouse had dementia, drawing comparisons with the approaches used prior to the illness. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The aging of the U.S. population has resulted in a large number of persons with multiple, chronic illnesses and gradual functional decline. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
On the basis of these results, we recommend that discussions that include NHPs, family members, and nurses concerning decisions about possible future situations be held on a regular basis. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
A retrospective case note audit was conducted in order to determine the most prevalent symptoms in terminal dementia and to assess the palliation given. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
We developed a mostly consensus-based practice guideline for patients with dementia and pneumonia and mapped controversial issues for future investigation. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The increasing burden of chronic disease demands that palliative care clinicians address the needs of patients with non-malignant disease. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Structural MRIs of the brains of humans with extensive navigation experience, licensed London taxi drivers, were analyzed and compared with those of control subjects who did not drive taxis. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
An extensive literature stretching back decades has shown that prolonged stress or prolonged exposure to glucocorticoids-the adrenal steroids secreted during stress-can have adverse effects on the rodent hippocampus. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Automated analysis of MRI data of the subregions of the hippocampus requires computational atlases built at a higher resolution than those that are typically used in current neuroimaging studies. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Childhood trauma is a potent risk factor for developing depression in adulthood, particularly in response to additional stress. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This study takes advantage of continuing advances in the precision of magnetic resonance imaging (MRI) to quantify hippocampal volumes in a series of human subjects with a history of depression compared with controls. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
These findings are consistent with a smaller right hippocampal volume in PTSD that is associated with functional deficits in verbal memory. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
In this review, we report on studies that have assessed the effects of exogenous and endogenous increases in stress hormones on human cognitive performance. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Antidepressants may have a neuroprotective effect during depression. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Stress-induced structural remodeling in the adult hippocampus, involving debranching and shortening of dendrites and suppression of neurogenesis, provides a cellular basis for understanding the impairment of neural plasticity in the human hippocampus in depressive illness. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
There is wide agreement that spatial memory is dependent on the integrity of the hippocampus, but the importance of the hippocampus for nonspatial tasks, including tasks of object recognition memory is not as clear. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Phenotypic expression of psychopathology may be strongly influenced by exposure to maltreatment, leading to a constellation of ecophenotypes. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The hippocampus plays an essential role in spatial learning. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Studies have examined hippocampal function and volume in depressed subjects, but none have systematically compared never-treated first-episode patients with those who have had multiple episodes. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
We have determined the volume and location of hippocampal tissue required for normal acquisition of a spatial memory task. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Normal volunteers, aged 30 to 99 years, were studied with MRI. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark in neurodegenerative disorders, including Alzheimer's disease. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
These data suggest that the overwhelming stress of maltreatment experiences in childhood is associated with adverse brain development. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →