28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
In this article we aim to present these recommendations and to invite professionals to consider these important issues and to contribute towards a broader discussion. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Four broad areas were identified as requiring complex decisions at the end of life; 1) eating/swallowing difficulties, 2) agitation/restlessness, 3) ending life-sustaining treatment, and 4) providing "routine care" at the end of life. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Over 40% of US NH decedents have mild-to-moderately severe or advanced dementia. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The aim of the present study was to clarify the processes of decision making and end-of-life care for patients with dementia in the group homes in Japan. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Most HCWs recognised a need for palliative care for people with PD; however several barriers to implementing a palliative care approach in this population need to be addressed. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
International experts selected a set of 23 QIs for the organisation of palliative care. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Hippocampal volumes of subjects with a history of major depressive episodes but currently in remission and with no known medical comorbidity were compared to matched normal controls by using volumetric magnetic resonance images. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Elevated glucocorticoid levels produce hippocampal dysfunction and correlate with individual deficits in spatial learning in aged rats. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The mind involves the whole body and two-way communication between the brain and the cardiovascular, immune, and other systems via neural and endocrine mechanisms. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Both the amygdala and the hippocampus are involved in the pathogenesis of a number of neurologic conditions, including temporal lobe epilepsy, postanoxic amnesia, and Alzheimer's disease. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Childhood maltreatment or abuse is a major risk factor for mood, anxiety, substance abuse, psychotic, and personality disorders, and it is associated with reduced adult hippocampal volume, particularly on the left side. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Loss of memory is among the first symptoms reported by patients suffering from Alzheimer's disease (AD) and by their caretakers. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Uncontrollable stress has been recognized to influence the hippocampus at various levels of analysis. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Brain areas implicated in the stress response include the amygdala, hippocampus, and prefrontal cortex. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
There is a reduction in the volume of amygdala and hippocampus in people with autism, particularly in relation to total brain volume. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Magnetic resonance imaging (MRI) has opened a new window to the brain. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The five-predictor combination strongly predicted conversion to AD and was markedly superior to combining age and MMSE. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
We investigated the relationship between preoperative MRI hippocampal volumes and clinical neuropsychological memory test data obtained before and after temporal lobectomy and amygdalohippocampectomy for intractable epilepsy in 44 left (LTL) and 36 right (RTL) temporal lobectomy patients. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Exposure to elevated levels of PM2.5 was associated with smaller total cerebral brain volume, a marker of age-associated brain atrophy, and with higher odds of covert brain infarcts. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This is the first study to show aberrant regulation of the protein synthesis machinery in the suicide brain. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Nuclear magnetic resonance (NMR) imaging was employed to study 10 patients with Alzheimer's disease (AD) and seven healthy elderly control subjects. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Alzheimer's disease is the most common neurodegenerative disorder in the elderly. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The cornu ammonis 1 region of the hippocampus (CA1) sector of hippocampus is vulnerable to both Alzheimer's disease (AD)-type neurofibrillary degeneration and anoxia-ischemia. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Borderline personality disorder (BPD) is a common disorder associated with emotional dysregulation and other symptoms that have been hypothesized to be related to dysfunction of limbic brain areas including hippocampus and amygdala. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Our findings support the theory that alterations in hippocampal glutamate levels potentially account for structural deficits in the hippocampus observed in schizophrenia neuroimaging studies. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →