In patients with end-stage renal disease, nervous system dysfunction remains a major cause of disability. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research
28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
Prevalence of dementia continues to increase because of the aging population and limited treatment options. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The authors identified 2 Class I studies, 8 Class II studies, and 30 Class III studies in ALS, but many important areas have been little studied. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Palliative care (PC) has focused on patients with cancer within specialist services. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Chronic heart failure (CHF) is the leading cause of hospitalization for those over the age of 65 and represents a significant clinical and economic burden. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Place of death of older people who died from a dementia-related disease differs substantially between countries, which might point to organizational differences in end-of-life care provision. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Bereaved family members of people with dementia who received hospice reported higher perceptions of the quality of care and quality of dying. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Regardless of the dementia stage, many nursing home residents develop serious clinical complications and symptoms in the last phase of life, posing major challenges to the provision of optimum end-of-life care. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Communication regarding care is rarely patient driven and more often professional caregiver or family driven. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
40/100
It is difficult to define what constitutes high-quality end-of-life care for people with dementia from the perspective of family carers. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
When planning an improvement project in PC, services should pay particular attention to factors associated with their chosen implementation strategy. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Future palliative care policy decisions in Ireland must consider the rapidly aging Irish population with the accompanying increase in deaths from cancer, dementia, and neurodegenerative disease and associated palliative care need. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Studies have found no evidence that feeding tubes in this population prevent aspiration, prolong life, improve overall function, or reduce pressure sores. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The NH culture influences the approach to feeding in advanced cognitive impairment, whether by hand or placement of a feeding tube. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Approaches to palliative care that were originally developed for people with cancer are now being adopted for people with dementia, as a response to many reports of poor-quality care for people with dementia at the end of life. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
40/100
These are not problems distinct to palliative care, but they may have different origins and explanations compared to other areas of health care. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The Medicare hospice benefit was originally designed around a cancer disease paradigm but increasingly serves people living with dementia. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Dementia, with a high incidence rate, fast-developing syndrome and large disease burden, raises challenges to global health and social systems. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Even among patients with early cognitive impairment seen in specialty clinics and their caregivers, most were unaware of the decisions they could face, and there were many barriers to planning for these decisions. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The ongoing change in long-term care from institutional care to housing services causes major challenges to the continuity of end-of-life care. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
40/100
The American Society for Parenteral and Enteral Nutrition (ASPEN) Position Paper focus is on applying the 4 ethical principles for clinician's decision-making in the use of artificially administered nutrition and hydration (AANH) for adult and pediatric patients. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This qualitative study about the experiences and perceptions of family carers of people with a chronic life-limiting illness living at home regarding the collaboration with different healthcare providers in the last phase life, showed that family carers experience a lot of possibilities, but perceive missed opportunities as well, for healthcare professionals to effectively collaborate with them for palliative care. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
ACP practices are evolving. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The results of the study identified that professionals across Europe have different opinions regarding the time point when to consider a person with dementia in need of palliative care. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
For people with dementia living and dying in care homes, EoL interventions need to provide strategies that can accommodate or "hold" the inevitable and often unresolvable uncertainties of providing and receiving care in these settings. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →