When growing older, many people are faced with cognitive deterioration, which may even amount to a form of dementia at some point in time. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research
28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
Lifelong bilingualism is associated with delayed dementia onset, suggesting a protective effect on the brain. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Cognitive reserve (CR) is known to reduce or even protect against the negative effects of aging on cognitive functioning. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research supporting cognitive reserve theory suggests that engaging in a variety of cognitive, social, and physical activities may serve as protective factors against age-related changes in mental functioning, especially if the activities are cognitively engaging. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The human lifespan has expanded drastically in the last few centuries, due to improvements in sanitation, medicine, and nutrition, but with this increase in longevity comes higher rates of cognitive pathology such as mild cognitive impairment (MCI) and dementia; the latter is estimated to reach more than 75 million people by 2030. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Cognitive reserve is originally an epidemiological concept that encompasses individual abilities to cope with changes. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
41/100
Quality of education was positively correlated with both educational attainment and cognitive performance. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Physical Activity and Mental Health in the Elderly Abstract. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Alzheimer's Disease (AD) is the leading cause of dementia, observed at a higher incidence in women compared with men. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Cognitive disorders are frequently found during late-life depression (LLD). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Loneliness imposes significant risks to physical, mental and brain health in older adulthood. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
This review describes associations between dementia and loneliness on the neurobiological and epidemiological levels according to the recent body of literature. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
With the unprecedented aging of the world's population, the number of elderly patients with depression is expected to increase. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
This article provides a current review of the literature examining caffeine use in older adults. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Late-life depression is frequently associated with cognitive impairment. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
41/100
in multi-adjusted models, relative to individuals without depression, those with major (β per year: 0.33, 95% confidence interval [CI]: 0.06-0.61) and subsyndromal depression (β per year: 0.21, 95%CI: 0.12-0.30) experienced an accelerated rate of somatic multimorbidity accumulation, whereas those with minor depression did not. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Coupled with aging, chronic stress experienced by dementia caregivers often leads to deteriorating health. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Affective computing (also referred to as artificial emotion intelligence or emotion AI) is the study and development of systems and devices that can recognize, interpret, process, and simulate emotion or other affective phenomena. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Late-life depression (LLD) is associated with an increased risk of all-cause dementia and may involve Alzheimer's disease pathology. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Nursing leaders have a responsibility to promote and facilitate social engagement and connectedness to mitigate social isolation in long-term care (LTC). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Social connection is an understudied target of intervention for the health of individuals providing care for a family member with Alzheimer's disease and related dementias (ADRD). 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
World is greying as the proportion of the ageing population increases and the demography is changing both in the developing and developed world. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
In older age, frailty is a detrimental transitional status of the aging process featuring an increased susceptibility to stressors defined by a clinical reduction of homoeostatic reserves. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Social concepts such as loneliness and social isolation are fairly new factors that have been recently gaining attention as to their involvement in changes in cognitive function and association with dementia. 1 key finding →
Design: narrative review Evidence: low
Full summary, score breakdown and related studies → Original source
41/100
The current review has the ultimate scope to accurately define social isolation and loneliness while highlighting the serious repercussions on health and behavior. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →