Delirium affects 60 to 80% of ventilated patients and is associated with worse clinical outcomes including death. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research
27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
Dementia and hip fractures are 2 conditions that are seen primarily in older adults, and both are associated with substantial morbidity and mortality. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Most decline occurred prior to hospitalization and was associated with common indicators of poor outcomes in hospitalized elders. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
With the upcoming reform of the healthcare system and the greater emphasis on care in the home and other living environments, geriatric providers will need alternate ways of monitoring disease, activity, response to therapy, and patient safety. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
We report the clinical features of the original Chilean family with Kufor-Rakeb syndrome (KRS) that led to the discovery of the ATP13A2 gene at the PARK9 locus. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The blood-brain barrier (BBB) represents the interface between the brain and other body tissues. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research on end-of-life care for people with dementia has yet to develop interventions that address the particular challenges that dying with dementia poses. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The number of people with dementia will rise dramatically over the next 20 years. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Recent years have seen a growing recognition that dementia is a terminal illness and that patients with advanced dementia nearing the end of life do not currently receive adequate palliative care. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
More than two-thirds of long-stay nursing home residents suffer from dementia. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The goals of palliative care address critical issues for individuals with complex and serious illness residing in nursing homes, including pain and symptom management, communication, preparation for death, decisions about treatment preferences, and caregiver support. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Each vignette promoted discussion of differences of perspectives about the ways to enhance the dignity of people with dementia in hospital, care home and community settings. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
This pilot study examined whether an interactive, computer based decision aid can help patients with amyotrophic lateral sclerosis (ALS) engage in effective advance care planning. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
36/100
Over the years 2005-2006, many ECPs took care of patients with dementia and an ADE, actual life termination of these patients took place very rarely and never in incompetent patients. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Because children are becoming overweight, unhealthy, and unfit, understanding the neurocognitive benefits of an active lifestyle in childhood has important public health and educational implications. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The patterns of subfield atrophy in AD and MCI were consistent with patterns of neuronal cell loss/reduced synaptic density described by histopathology. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Prior work has demonstrated that the memory dysfunction of Alzheimer's disease (AD) is accompanied by marked cortical pathology in medial temporal lobe (MTL) gray matter. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Imaging studies have consistently documented hippocampal volume reductions in depression. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The hippocampus is abnormal in schizophrenia. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
However, a more recent work, derived in part from functional neuroimaging studies, has suggested that other brain structures make up a large-scale network that appears to support successful encoding and retrieval of episodic memories. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Compared with individuals at low familial risk of the development of depression, high-risk individuals have reduced hippocampal volume, indicating that neuroanatomic anomalies associated with depression may precede the onset of a depressive episode and influence the development and course of this disorder. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The hippocampal volume increases after ECT, supporting the hypothesis that hippocampus may play a central role in the treatment of depression. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Iron has a role in brain injury after IVH. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Lower volume in the right hippocampus in chronic cannabis users was corroborated. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The present results suggest that OXTR might be associated with the susceptibility to ASD, especially in its aspects of social interaction and communication mediated by a modulation of amygdala development, one of the most distributed brain regions with high density of OXTR. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →