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Research

27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.

Find studies

Showing 476–500 of 739 studies published 2012 (page 20 of 30) · 27,380 in the whole library · How the 0–100 score works

Browse by subject, author or institution

Each number is how many studies that link shows, with your other filters kept.

Subjects

Authors

Names as each record prints them; the same person can appear under two spellings.

Institutions

From OpenAlex; 12,859 studies have no institution on record and are not counted here.

A note on reading research. One study is rarely the final word.

We try to note the size of a study, whether it was in humans or animals, and how early-stage the finding is. If a summary here doesn't make that clear, treat it with extra caution and check the original source.

Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors

✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neurology, neurosurgery, and psychiatry 2012-11-07

This study demonstrates permanent cognitive impairment in several domains in both septic and non-septic ICU survivors and unspecific brain dysfunction. 3 key findings →

Participants: 25 Evidence: low

Full summary, score breakdown and related studies → Original source

Mitochondria-associated ER membranes in Alzheimer disease

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular and cellular neurosciences 2012-08-24

Alzheimer disease (AD) is associated with the accumulation in the brain of extracellular neuritic plaques composed mainly of β-amyloid (Aβ) and of intracellular neurofibrillary tangles composed of hyperphosphorylated forms of the microtubule-associated protein tau. 5 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Brain excitability and connectivity of neuronal assemblies in Alzheimer's disease: from animal models to human findings

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Progress in neurobiology 2012-07-10

The human brain contains about 100 billion neurons forming an intricate network of innumerable connections, which continuously adapt and rewire themselves following inputs from external and internal environments as well as the physiological synaptic, dendritic and axonal sculpture during brain maturation and throughout the life span. 5 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Frontotemporal lobar degeneration: epidemiology, pathology, diagnosis and management

✓ Peer-reviewed alzhub usefulness score 43 out of 100. CNS drugs 2012-10-01

Frontotemporal lobar degeneration (FTLD) describes a spectrum of clinically, pathologically and genetically heterogeneous neurodegenerative disorders of unknown aetiology. 1 key finding →

Evidence: low

Full summary, score breakdown and related studies → Original source Full text may need a subscription

APP mutations in the Aβ coding region are associated with abundant cerebral deposition of Aβ38

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Acta neuropathologica 2012-11-13

Aβ is the main component of amyloid deposits in Alzheimer disease (AD) and its aggregation into oligomers, protofibrils and fibrils is considered a seminal event in the pathogenesis of AD. 2 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Using virtual reality to characterize episodic memory profiles in amnestic mild cognitive impairment and Alzheimer's disease: influence of active and passive encoding

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neuropsychologia 2012-01-13

Third, we benchmarked the results of our virtual reality episodic memory test against a classical memory test and a subjective daily memory complaint scale. 3 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Antioxidants & redox signaling 2012-02-07

Alzheimer's disease (AD) is the most common cause of dementia and a progressive neurodegeneration that appears to result from multiple pathogenic mechanisms (including protein misfolding/aggregation, involved in both amyloid β-dependent senile plaques and tau-dependent neurofibrillary tangles), metabolic and mitochondrial dysfunction, excitoxicity, calcium handling impairment, glial cell dysfunction, neuroinflammation, and oxidative stress. 3 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Contributions of the Framingham Heart Study to stroke and dementia epidemiologic research at 60 years

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Archives of neurology 2012-05-01

The Framingham Heart Study, the longest-running prospective epidemiologic study in history, was initiated in 1948 in response to the rising toll of coronary heart disease and hypertension. 4 key findings →

Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Mediterranean diet and longevity in Sicily: survey in a Sicani Mountains population

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Rejuvenation research 2012-04-01

Over the past several years, increasing evidence suggests that the Mediterranean diet has a beneficial influence on several age-related diseases, showing protective effect on health and longevity. 2 key findings →

Participants: 15 Evidence: low

Full summary, score breakdown and related studies → Original source

Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Anesthesiology 2012-04-01

This is the first prospective study employing validated measures of delirium to identify an association between preexisting obstructive sleep apnea and postoperative delirium. 5 key findings →

Participants: 15 Evidence: low

Full summary, score breakdown and related studies → Original source

A qualitative study: professionals' experiences of advance care planning in dementia and palliative care, 'a good idea in theory but ...'

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Palliative medicine 2012-11-21

This study has identified the professional, organisational and legal factors that influence advance care planning implementation; professional training should target these specific areas. 2 key findings →

Participants: 95 Evidence: low

Full summary, score breakdown and related studies → Original source

Barriers to providing end-of-life care for people with dementia: a whole-system qualitative study

✓ Peer-reviewed alzhub usefulness score 43 out of 100. BMJ supportive & palliative care 2012-03-01

Qualitative methods of service evaluation facilitated a broader and deeper understanding of a range of perspectives, which, with other components of rapid participatory appraisal, generated potential solutions to improve care. 1 key finding →

Participants: 50 Evidence: low

Full summary, score breakdown and related studies → Original source

Does case conferencing for people with advanced dementia living in nursing homes improve care outcomes: evidence from an integrative review?

✓ Peer-reviewed alzhub usefulness score 43 out of 100. International journal of nursing studies 2012-11-28

Case conferencing provides opportunities to improve care palliative care outcomes for older people with dementia by engaging family and all relevant internal and external health providers in prospective care planning. 4 key findings →

Evidence: high

Full summary, score breakdown and related studies → Original source

Preferences for end-of-life treatment: concordance between older adults with dementia or mild cognitive impairment and their spouses

✓ Peer-reviewed alzhub usefulness score 43 out of 100. International psychogeriatrics 2012-05-22

Our results show that regarding end-of-life preferences for patients, there is moderate agreement between patients and their spouses, but limited evidence for projection of spouses' preferences on patients (i.e. spouse making a prediction based on own wishes). 2 key findings →

Design: cross-sectional Evidence: low

Full summary, score breakdown and related studies → Original source

Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Brain, behavior, and immunity 2012-06-12

Many survivors of breast cancer show significant cognitive impairments, including memory deficits. 5 key findings →

Design: cross-sectional Evidence: low

Full summary, score breakdown and related studies → Original source

Spatial navigation impairment is proportional to right hippocampal volume

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2012-01-30

Cognitive deficits in older adults attributable to Alzheimer's disease (AD) pathology are featured early on by hippocampal impairment. 3 key findings →

Participants: 23 Evidence: low

Full summary, score breakdown and related studies → Original source

Long-term declarative memory deficits in diffuse TBI: correlations with cortical thickness, white matter integrity and hippocampal volume

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Cortex; a journal devoted to the study of the nervous system and behavior 2012-03-08

We investigated structural brain damage in subjects who had suffered severe and diffuse traumatic brain injury (TBI), and examined its relationship with declarative memory impairment. 5 key findings →

Participants: 26 Evidence: low

Full summary, score breakdown and related studies → Original source

Transthyretin decrease in plasma of MCI and AD patients: investigation of mechanisms for disease modulation

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Current Alzheimer research 2012-10-01

Different authors described that transthyretin (TTR) is decreased in the cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients and thus TTR is a potential CSF biomarker in AD. 4 key findings →

Participants: 55 Evidence: low

Full summary, score breakdown and related studies → Original source

Validity of a brief computerized cognitive screening test in dementia

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of geriatric psychiatry and neurology 2012-06-01

CogState and standard neuropsychological task scores were significantly lower for dementia participants than that of the nondementia groups (P < .05), with a single CogState test distinguishing control from MCI participants, but minimal differentiation existing between dementias using the CogState. 2 key findings →

Participants: 37 Evidence: low

Full summary, score breakdown and related studies → Original source

Organochlorine pesticide levels and risk of Alzheimer’s disease in north Indian population

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Human & Experimental Toxicology 2012-08-16

Alzheimer's disease (AD) could result from a multifactorial process involving both genetic predisposition and exposure to environmental factors like pesticides. 3 key findings →

Participants: 70 Evidence: low

Full summary, score breakdown and related studies → Original source

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Where “Free full text” comes from

Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read

How the 0–100 score works — and why some entries are capped

This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.

  • Journal tier up to 10 pts
  • Journal's citation record up to 4 pts
  • Study design up to 12 pts
  • Strength of evidence up to 5 pts
  • Peer-review validation up to 10 pts
  • How recent up to 5 pts
  • Sample size up to 4 pts
  • Effect reported up to 3 pts
  • Studied in people up to 3 pts
  • Randomised / blinded up to 2 pts
  • Times cited up to 7 pts
  • Citations per year up to 5 pts
  • Impact for its field and year up to 6 pts
  • Cited by studies here up to 6 pts
  • Still being cited up to 4 pts
  • Senior author's track record up to 4 pts
  • Institution's track record up to 3 pts
  • Multi-centre collaboration up to 3 pts
  • Indexed in PubMed up to 2 pts
  • Free to read up to 2 pts

Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.

Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.

We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.

The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.

See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.

What this library is — and isn't

This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.

1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.

See the full, machine-readable breakdown of this library's coverage →

Newest studies, as a dated timeline →    Atom feed