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Research

27,780 Alzheimer's and dementia studies in plain English, each scored out of 100.

Find studies

Showing 26–50 of 154 studies with an author at Wake Forest University (US) (page 2 of 7) · 27,780 in the whole library · How the 0–100 score works

Download bibliography of these 154 studies, in this order: BibTeX (.bib) · RIS (.ris)

Browse by subject, author or institution

Each number is how many studies that link shows, with your other filters kept.

Subjects

Authors

Names as each record prints them; the same person can appear under two spellings.

Other institutions

From OpenAlex; 13,259 studies have no institution on record and are not counted here.

A note on reading research. One study is rarely the final word.

We try to note the size of a study, whether it was in humans or animals, and how early-stage the finding is. If a summary here doesn't make that clear, treat it with extra caution and check the original source.

Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

✓ Peer-reviewed alzhub usefulness score 73 out of 100. PLoS medicine 2018-01-25

We found that distinct sphingolipid species including sphingomyelin (SM) with acyl residue sums C16:0, C18:1, and C16:1 (SM C16:0, SM C18:1, SM C16:1) and hydroxysphingomyelin with acyl residue sum C14:1 (SM (OH) C14:1) were consistently associated with severity of AD pathology at autopsy and AD progression across prodromal and preclinical stages. 5 key findings →

Design: longitudinal study Participants: 44 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Midlife and late‐life population attributable fractions of risk factors for dementia in the United States: The Dementia Risk Prediction Project

✓ Peer-reviewed alzhub usefulness score 73 out of 100. Alzheimer s & Dementia 2026-01-01

Midlife and late-life risk factors contributed to 22.7% and 16.5% of total dementia cases, respectively. 5 key findings →

Design: meta-analysis Participants: 37,931 Evidence: high

Full summary, score breakdown and related studies → Original source Free full text

Effects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study

✓ Peer-reviewed alzhub usefulness score 72 out of 100. Alzheimer's & Dementia 2025-04-24

Exercise intensity did not differentially affect cognitive trajectory. 2 key findings →

Design: phase-3-trial Participants: 296 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Multidomain lifestyle intervention for the prevention of cognitive decline in at-risk older adults in Latin America (LatAm-FINGERS): a single-blind, multicentre, randomised controlled trial

✓ Peer-reviewed alzhub usefulness score 72 out of 100. The Lancet 2026-07-13

These findings extend the evidence base for multidomain lifestyle interventions to populations historically under-represented in dementia research, supporting their feasibility and scalability as strategies to reduce cognitive decline risk amid the rapidly growing burden of dementia in low-income and middle-income countries. 3 key findings →

Design: RCT Participants: 1,065 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial

✓ Peer-reviewed alzhub usefulness score 72 out of 100. JAMA 2003-05-01

The mean (SD) time between the date of randomization into WHI and the last Modified Mini-Mental State Examination (3MSE) for all WHIMS participants was 4.05 (1.19) years. 5 key findings →

Participants: 2,229 Evidence: high

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort

✓ Peer-reviewed alzhub usefulness score 72 out of 100. Journal of the American Geriatrics Society 2005-07-01

Older adults with CVD other than stroke had a higher risk of dementia and AD than did those without CVD. 5 key findings →

Design: cohort study Participants: 3,602 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial

✓ Peer-reviewed alzhub usefulness score 72 out of 100. Diabetes care 2009-02-01

A statistically significant age-adjusted association was observed between the A1C level and the score on all four cognitive tests. 3 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Machine Learning-Based Sleep Electroencephalographic Brain Age Index and Dementia Risk: An Individual Participant Data Meta-Analysis

✓ Peer-reviewed alzhub usefulness score 71 out of 100. JAMA network open 2026-03-02

Across the cohorts, each 10-year increase in BAI was associated with a 39% higher risk of incident dementia (hazard ratio [HR], 1.39 [95% CI, 1.21-1.59]; P Conclusions and relevance In this IPD meta-analysis, a higher sleep EEG-based BAI was associated with a higher risk of incident dementia. 3 key findings →

Design: meta-analysis Participants: 7,105 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Association of Intensive vs Standard Blood Pressure Control With Magnetic Resonance Imaging Biomarkers of Alzheimer Disease: Secondary Analysis of the SPRINT MIND Randomized Trial

✓ Peer-reviewed alzhub usefulness score 71 out of 100. JAMA neurology 2021-05-01

Intensive treatment was associated with a small but statistically significant greater decrease in hippocampal volume compared with standard treatment, consistent with the observation that intensive treatment is associated with greater decreases in total brain volume. 5 key findings →

Design: meta-analysis Participants: 1,267 Evidence: high

Full summary, score breakdown and related studies → Original source Free full text

Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study

✓ Peer-reviewed alzhub usefulness score 71 out of 100. The journals of gerontology. Series A, Biological sciences and medical sciences 2017-10-01

Recruitment ended in December 2014 with 16,703 Australian and 2,411 U.S. participants, a median age of 74 (range 65-98) years and 56% women. 1 key finding →

Evidence: high

Full summary, score breakdown and related studies → Original source Free full text

Effect of tai chi on cognitive performance in older adults: systematic review and meta-analysis

✓ Peer-reviewed alzhub usefulness score 70 out of 100. Journal of the American Geriatrics Society 2014-01-02

Tai Chi shows potential to enhance cognitive function in older adults, particularly in the realm of executive functioning and in individuals without significant impairment. 5 key findings →

Design: systematic review Participants: 2,553 Evidence: high

Full summary, score breakdown and related studies → Original source Free full text

Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer's disease

✓ Peer-reviewed alzhub usefulness score 70 out of 100. Brain : a journal of neurology 2020-01-01

Therefore, we conducted a longitudinal study to examine whether PM2.5 affects the episodic memory decline, and also explored the potential mediating role of increased neuroanatomic risk of Alzheimer's disease associated with exposure. 5 key findings →

Design: longitudinal study Participants: 998 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Association of Pace of Aging Measured by Blood-Based DNA Methylation With Age-Related Cognitive Impairment and Dementia

✓ Peer-reviewed alzhub usefulness score 70 out of 100. Neurology 2022-07-06

DNA methylation algorithms are increasingly used to estimate biological aging; however, how these proposed measures of whole-organism biological aging relate to aging in the brain is not known. 4 key findings →

Design: longitudinal study Participants: 649 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Plasma Phosphorylated Tau 217 and Incident Mild Cognitive Impairment and Dementia in Older Women

✓ Peer-reviewed alzhub usefulness score 69 out of 100. JAMA Network Open 2026-03-02

Among 2766 participants (mean [SD] age, 69.9 [3.8] years; 486 [17.9%] Black, 196 [7.1%] Hispanic, and 2007 [73.9%] White), 1311 developed the combined end point of MCI or dementia (849 participants with MCI and 752 participants with dementia). 5 key findings →

Design: cohort Participants: 2,766 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

The Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes Study (ACCORD-MIND): rationale, design, and methods

✓ Peer-reviewed alzhub usefulness score 69 out of 100. The American journal of cardiology 2007-04-12

Type 2 diabetes mellitus and cognitive impairment are 2 of the most common chronic conditions found in persons aged > or = 60 years. 1 key finding →

Participants: 2,977 Evidence: high

Full summary, score breakdown and related studies → Original source Free full text

Sleep duration, cognitive decline, and dementia risk in older women

✓ Peer-reviewed alzhub usefulness score 68 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2015-06-15

In older women, habitual sleep duration predicts the future risk for cognitive impairments including dementia, independent of vascular risk factors. 1 key finding →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial

✓ Peer-reviewed alzhub usefulness score 67 out of 100. JAMA neurology 2013-08-01

Baseline levels of LD Aβ were greater for adults with mild cognitive impairment compared with adults with normal cognition (LD Aβ42, P = .05; LD Aβ40, P = .01). 3 key findings →

Evidence: high

Full summary, score breakdown and related studies → Original source Free full text

Association of Echocardiographic Measures of Left Atrial Function and Size With Incident Dementia

✓ Peer-reviewed alzhub usefulness score 67 out of 100. JAMA 2022-03-01

In this exploratory analysis of a US community-based cohort, several echocardiographic measures of lower LA function were significantly associated with an increased risk of subsequent dementia. 5 key findings →

Design: prospective cohort Participants: 4,096 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2

✓ Peer-reviewed alzhub usefulness score 66 out of 100. Archives of neurology 2003-10-01

The development of MCI is associated with measurements of cognition and depression, racial and constitutional factors, and cerebrovascular disease. 5 key findings →

Design: longitudinal study Participants: 927 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke

✓ Peer-reviewed alzhub usefulness score 66 out of 100. PLoS genetics 2014-03-20

Circulating homocysteine levels (tHcy), a product of the folate one carbon metabolism pathway (FOCM) through the demethylation of methionine, are heritable and are associated with an increased risk of common diseases such as stroke, cardiovascular disease (CVD), cancer and dementia. 4 key findings →

Design: meta-analysis Participants: 2,710 Evidence: high

Full summary, score breakdown and related studies → Original source Free full text

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Where “Free full text” comes from

Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read

How the 0–100 score works — and why some entries are capped

This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.

  • Journal tier up to 10 pts
  • Journal's citation record up to 4 pts
  • Study design up to 12 pts
  • Strength of evidence up to 5 pts
  • Peer-review validation up to 10 pts
  • How recent up to 5 pts
  • Sample size up to 4 pts
  • Effect reported up to 3 pts
  • Studied in people up to 3 pts
  • Randomised / blinded up to 2 pts
  • Times cited up to 7 pts
  • Citations per year up to 5 pts
  • Impact for its field and year up to 6 pts
  • Cited by studies here up to 6 pts
  • Still being cited up to 4 pts
  • Senior author's track record up to 4 pts
  • Institution's track record up to 3 pts
  • Multi-centre collaboration up to 3 pts
  • Indexed in PubMed up to 2 pts
  • Free to read up to 2 pts

Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.

Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.

We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.

The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.

See the whole rubric drawn out → — four charts covering all 27,780 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.

What this library is — and isn't

This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,780 records, built mostly from automated pulls of Europe PMC (61.1% of the library) and OpenAlex (18.3%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.

1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.

See the full, machine-readable breakdown of this library's coverage →

Newest studies, as a dated timeline →    Atom feed