Alzheimer's disease (AD) is characterized by cognitive dysfunction and progressive neurodegeneration. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
Alzheimer's disease (AD) is characterized by cognitive dysfunction and progressive neurodegeneration. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Alzheimer's disease (AD) is recognized as multifactorial and heterogeneous disease with multiple contributors to its pathophysiology, including vascular dysfunction. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The relationship between arterial hypertension and cognitive decline, two among the conditions with higher prevalence in the elderly population, has gained significant interest, in the scientific community, during the last few years, stemming from the numerous epidemiologic, experimental, and therapeutic evidences suggesting a non-casual correlation between the two conditions. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Alzheimer's disease is characterized by aggregated amyloid beta plaques and neurofibrillary tangles. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Metabolic syndrome (MetS) is an association between obesity, dyslipidemia, hyperglycemia, hypertension, and insulin resistance. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Large artery stiffness is a frequent condition that arises with ageing, and is accelerated by the presence of co-morbidities like hypertension, obesity and diabetes. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Neurodegenerative disorders are the most devastating disorder of the nervous system. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Similar to other complex disorders, the etiology of Alzheimer disease is multifactorial and characterized by an interplay of biological and environmental risk and protective factors. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research into cognitive reserve (CR) and dementia is advancing rapidly. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The MoCA reflected total CRIq score (CRI; B = 0.076, P < 0.001), CRI-Education (B = 0.066, P < 0.001), and CRI-Working activity (B = 0.025, P = 0.042), while MMSE reflected total CRI (B = 0.044, P < 0.001) and CRI-Education (B = 0.049, P < 0.001) only. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Genetically predisposition to longer educational attainment and harder math class taken were associated with significantly lower statistical odds ratio of ALS. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Patients with comparable degree of neuropathology could show different cognitive impairments. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Despite the large number of elderly bilinguals at risk for Alzheimer's disease (AD) and dementia worldwide, significant questions remain about the relationship between speaking more than one language and later cognitive decline. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Higher early-life CR (hazard ratio = 0.48, 95% CI = [0.21; 1.06]) but not early-life BR associated with a lower risk of incident dementia. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Alzheimer's disease (AD) is the most common form of dementia, with no means of cure or prevention. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Level of education is often regarded as a proxy for cognitive reserve in older adults. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Brain age prediction is a machine learning method that estimates an individual's chronological age from their neuroimaging scans. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Cognitive reserve beneficially affects cognitive performance, even into advanced age. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This article covers current research on the relationship between depression and cognitive impairment in older adults. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Three major neurobiological features shared by LLD and AD include neurodegeneration, disruption to cerebrovascular functioning, and increased levels of neuroinflammation. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This article covers current research on the relationship between depression and cognitive impairment in older adults. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
We then review new research on moderators of clinical response and how to use the information for improved efficacy. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Caregivers of individuals with dementia are at risk for chronic stress and social isolation. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This article appraises several facets of the linkage between depression and cognitive impairment, including dementia, mild cognitive impairment, and vascular dementia. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →