We review the cellular and physiological mechanisms responsible for the regulation of blood flow in the retina and choroid in health and disease. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research
27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
Alternatively, compounds found in certain foods may be able to significantly bolster biological resistance against oxidants. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
36/100
Melatonin, an endogenous signal of darkness, is an important component of the body's internal time-keeping system. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Originally considered an enigmatic protein, the sigma-1 receptor has recently been identified as a unique ligand-regulated molecular chaperone in the endoplasmic reticulum of cells. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Noninvasive monitoring of β-amyloid (Aβ) plaques, the neuropathological hallmarks of Alzheimer's disease (AD), is critical for AD diagnosis and prognosis. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Astrocyte activation and reactive gliosis accompany most of the pathologies in the brain, spinal cord, and retina. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Photoreceptor cells are incessantly bombarded with photons of light, which, along with the cells' high rate of oxygen metabolism, continuously exposes them to elevated levels of toxic reactive oxygen intermediates (ROIs). 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Copper is an essential trace metal which plays a fundamental role in the biochemistry of the human nervous system. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Sleep disruption appears to be a core component of Alzheimer's disease (AD) and its pathophysiology. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The cytokine interleukin-6 (IL-6) plays a critical role in the pathogenesis of inflammatory disorders and in the physiological homeostasis of neural tissue. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The aggregation of proteins is central to many aspects of daily life, including food processing, blood coagulation, eye cataract formation disease and prion-related neurodegenerative infections. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in older individuals worldwide. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Macroautophagy is an important route in cellular maintenance, in the breakdown and reuse of intracellular materials. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Neurodegeneration in the brains of Huntington's disease patients is accompanied by widespread changes in gene regulatory networks. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Glaucoma is a leading cause of irreversible world vision loss characterized by progressive retinal ganglion cell death. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Scavenger receptor class A (SR-A, CD204), scavenger receptor-BI (SR-BI), and CD36 are cell surface proteins that mediate cell adhesion to, and endocytosis of, various native and pathologically modified substances, and participate in intracellular signaling, lipid metabolism, and host defense against bacterial pathogens. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share phenotypic and pathologic overlap. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This paper reviews recent progress in the diagnosis of Alzheimer's disease (AD) from electroencephalograms (EEG). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Basic and clinical research accomplished during the last few years on embryonic, fetal, amniotic, umbilical cord blood, and adult stem cells has constituted a revolution in regenerative medicine and cancer therapies by providing the possibility of generating multiple therapeutically useful cell types. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The development of the devastating neurodegenerative condition, Alzheimer's disease, is strongly associated with amyloid-beta (Abeta) deposition, neuronal apoptosis, and cell loss. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The pineal gland is a central structure in the circadian system which produces melatonin under the control of the central clock, the suprachiasmatic nucleus (SCN). 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
A time-dependent release of endogenous free DHA followed by NPD1 formation occurs, suggesting that a phospholipase A2 releases the mediator's precursor. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
36/100
In Alzheimer's disease (AD), brain lesions are marked by severe neuronal loss and retinal degeneration was previously mentioned in affected patients. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The essential fatty acids (EFAs), particularly the n-3 long-chain polyunsaturated fatty acids (LCPs), are important for brain development during both the fetal and postnatal period. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The neural pathways and brain regions involved in eye movements during ocular fixation and gaze control include the cerebrum, brainstem and cerebellum, and abnormal eye movements can indicate the presence of neurodegeneration. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →