27,780 Alzheimer's and dementia studies in plain English, each scored out of 100.
An 82-year-old man presented with progressive changes in personality, social conduct, and executive function with preservation of memory, deteriorating from baseline to requiring acute hospitalization within 6 months. 1 key finding →
Design: case report Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
This study has shown that physical restraints are used frequently in geriatric care in Sweden and that cognitive and physical impairments relate very closely to the use of physical restraints. 2 key findings →
Participants: 1,325 Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Probands (n = 3607) living in long-term care institutions in the county of Västerbotten were assessed to estimate whether the prevalence of dementia in different types of institutions had changed since a similar survey was made 7 years before. 5 key findings →
Participants: 3,607 Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
There is scarce information about the pathophysiological processes underlying Late-Life Depression (LLD). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Allostasis designates processes of bodily adaptation to stressful challenges, whereas allostatic load means the costs of wear and tear to the body as a consequence of inefficient allostasis. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Natural Language Processing (NLP) is an ever-growing field of computational science that aims to model natural human language. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Smart mobile and wearable technology offers exciting opportunities to support people with dementia (PwD). 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
EDDA achieved an area under the receiver-operating characteristic curve (AUROC) of 0.85 in the test set and 0.93 in the validation set. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Recent advances in dementia research have expanded our understanding of modifiable risk factors, with air pollution being a well-established contributor. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Artificial intelligence and neuroimaging enable accurate dementia prediction but often involve 'black box' models that can be difficult to trust. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Hypertension remains a leading modifiable risk factor for cardiovascular and renal conditions and dementia. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
= 1), and three caregivers. Five key themes were identified, including ease of use, wearability, usefulness, transparency, and behavioral intention. 5 key findings →
Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
The Extra Trees model achieved up to 99% accuracy for personalized wristband data, while the multilayer perceptron model performed best in general models with 98% accuracy. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Alzheimer’s disease (AD) is a chronic neurological disease and one of the main causes of dementia in around the world. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
The presented results suggest the suitability of ecological handwriting analysis for the all-around monitoring of MCI, from early screening to disease progression evaluation. 4 key findings →
Participants: 57 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
HEK293, Neuro2a and SH-SY5Y expressing increased levels of α-synuclein were treated with sonicated α-synuclein pre-formed fibrils, to model seeded aggregation. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
IRMA can be used to learn and disregard center-specific information in features extracted from brain $$^{18}$$ 18 F-FDG PET scans, while retaining disease-specific information. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Of the 5200 participants (mean age = 71.0 years, 57.1% females), 302 (5.8%) were diagnosed with dementia. 5 key findings →
Participants: 2,080 Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
MAP-RTAP (AUC = 0.78) and pTau/Aβ42 (AUC = 0.76) were the best performing individual biomarkers. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
It is associated with various sociodemographic factors and health risks including dementia, depression, cardiovascular disease, and falls. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Post-translational modifications (PTMs) on tau have long been recognized as affecting protein function and contributing to neurodegeneration. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Structural magnetic resonance imaging (sMRI) has been widely used for computer-aided diagnosis of neurodegenerative disorders, e.g., Alzheimer's disease (AD), due to its sensitivity to morphological changes caused by brain atrophy. 5 key findings →
Evidence: moderate
Full summary, score breakdown and related studies → Original source
Brain functional imaging data, especially functional magnetic resonance imaging (fMRI) data, have been employed to reflect functional integration of the brain. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Cerebral small vessel disease (cSVD) has a crucial role in lacunar stroke and brain hemorrhages and is a leading cause of cognitive decline and functional loss in elderly patients. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The level of prediction error in the brain age estimation frameworks is associated with the authenticity of statistical inference on the basis of regression models. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,780 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,780 records, built mostly from automated pulls of Europe PMC (61.1% of the library) and OpenAlex (18.3%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →