28,580 Alzheimer's and dementia studies in plain English, each scored out of 100.
In this systematic review and meta-analysis of randomized clinical trials of patients with primarily noncancer illness, palliative care, compared with usual care, was statistically significantly associated with less acute health care use and modestly lower symptom burden, but there was no significant difference in quality of life. 4 key findings →
Design: systematic review Participants: 4,068 Evidence: high
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Subjective caregiver burden is a significant risk factor for depressive symptoms in carers of older people and may precipitate clinical depression. 4 key findings →
Design: meta-analysis Participants: 56 Evidence: high
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Where feasible, we combined data to obtain an overall estimate of effect. 4 key findings →
Evidence: high
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Recommendations for practice include development of standardized guidelines that address caregiver assessment, education, and resources; identification of "caregiver champions" in practice settings; provision of referrals to established support organizations for caregivers (eg, Cancer Support Community, Cancer Care); and collaboration among caregiving, professional, and cancer-related organizations to advocate policy and practice changes for family caregivers. 1 key finding →
Design: meta-analysis Evidence: high
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We estimated how all-cause mortality and cause-specific mortality in people with diabetes have changed over time, how the composition of the mortality burden has changed, and how this composition compared with that of the non-diabetes population. 2 key findings →
Design: longitudinal study Participants: 907 Evidence: moderate
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Evidence was weak for improving caregiver burdens in cancer and was absent for heart failure. 5 key findings →
Design: meta-analysis Evidence: high
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The incidence and prevalence of delirium in hospitals appears to be stable, though publication bias may have masked true changes. 5 key findings →
Design: systematic review Evidence: high
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This prospective study followed 392 older spousal caregivers and 427 non-caregivers for an average of 4.5 years. 3 key findings →
Design: cohort Participants: 819 Evidence: high
Full summary, score breakdown and related studies → Original source
Caring for a family member with dementia is generally regarded as a chronically stressful process, with potentially negative physical health consequences. 1 key finding →
Evidence: low
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All six short-form ZBI have very good validity, internal consistency, and discriminative ability. 2 key findings →
Participants: 105 Evidence: low
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Two longitudinal studies with different populations demonstrated that loneliness was a risk factor for the development of the pain, depression, and fatigue symptom cluster over time. 4 key findings →
Design: longitudinal study Participants: 115 Evidence: moderate
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Chronic kidney disease (CKD) is associated with poor outcomes, perhaps due to a high burden of comorbidity. 3 key findings →
Design: cohort study Participants: 530,771 Evidence: moderate
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The global burden associated with physical inactivity is substantial. 5 key findings →
Evidence: low
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The prevalence of geriatric ACHD is substantial, although severe lesions remain uncommon. 1 key finding →
Design: cohort study Participants: 3,239 Evidence: moderate
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This paper reports first-year, real-world results from one of the 96 'Established Track' organizations in the CMS GUIDE dementia care model, which launched nationally on July 1, 2024. 5 key findings →
Design: cohort Participants: 158 Evidence: early
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23% of the total global burden of disease is attributable to disorders in people aged 60 years and older. 5 key findings →
Evidence: low
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This study sought to determine the prevalence and impact of pain in a nationally representative sample of older adults in the United States. 3 key findings →
Participants: 7,601 Evidence: low
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Study objective Delirium's adverse effect on long-term mortality in older hospitalized patients is well documented, whereas its effect in older emergency department (ED) patients remains unclear. 4 key findings →
Design: cohort study Participants: 628 Evidence: moderate
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Previous research indicates that persons assigning values to ranges of health states consider some states to be worse than death. 2 key findings →
Evidence: low
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The finding that perceived social support is strongly related to well-being but unrelated to burden reinforces the conceptual distinctiveness of the latter two concepts. 3 key findings →
Participants: 243 Evidence: low
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The COVID-19 pandemic resulted in a large and dramatic shift to video-based telehealth use in home-based primary care. 1 key finding →
Design: cross-sectional Participants: 153 Evidence: low
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Unlike professional caregivers such as physicians and nurses, informal caregivers, typically family members or friends, provide care to individuals with a variety of conditions including advanced age, dementia, and cancer. 1 key finding →
Evidence: low
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The SHS global burden increased by 74% between 1990 and 2021 to almost 73·5 million individuals, with population growth accounting for only half of that increase. 5 key findings →
Evidence: low
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Our study suggests that being a caregiver who is experiencing mental or emotional strain is an independent risk factor for mortality among elderly spousal caregivers.
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By 2060, an estimated 48 million people (47% of all deaths globally) will die with serious health-related suffering, which represents an 87% increase from 26 million people in 2016. 83% of these deaths will occur in low-income and middle-income countries. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,580 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,580 records, built mostly from automated pulls of Europe PMC (62.2% of the library) and OpenAlex (17.8%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.6% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →