28,580 Alzheimer's and dementia studies in plain English, each scored out of 100.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for the major cause of dementia, and the increasing worldwide prevalence of AD is a major public health concern. 4 key findings →
Evidence: high
Full summary, score breakdown and related studies → Original source
Higher adherence to the MeDi is associated with reduced cerebrovascular disease burden. 3 key findings →
Participants: 46 Evidence: low
Full summary, score breakdown and related studies → Original source
Higher adherence to the MedDiet is associated with better cognitive function and lower risk of poor cognition in older UK adults. 5 key findings →
Evidence: moderate
Full summary, score breakdown and related studies → Original source
Given the reported health benefits of a Mediterranean diet (MedDiet) and delay in cognitive decline, we aimed to determine the level of adherence to a MedDiet using an 11-point scale and examine relationships with cognitive function and psychological well-being. 2 key findings →
Design: cross-sectional Evidence: low
Full summary, score breakdown and related studies → Original source
Some evidence suggests that strategies which target multiple factors simultaneously may prove more effective than those focusing on a single mechanism or domain. 4 key findings →
Evidence: high
Full summary, score breakdown and related studies → Original source
Systematic cognitive training produces long-term improvement in cognitive function and less difficulty in performing activities of daily living. 2 key findings →
Participants: 2,802 Evidence: low
Full summary, score breakdown and related studies → Original source
Aging induces cellular and molecular changes including modification of stem cell pools. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Circadian rhythms in elderly patients with severe dementia and behavioral disorders such as wandering, agitation and/or delirium were examined. 1 key finding →
Participants: 24 Evidence: low
Full summary, score breakdown and related studies → Original source
Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory failure. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The effects of acute sleep deprivation on β-amyloid (Aβ) clearance in the human brain have not been documented. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia defined by intermittent loss of electromyographic atonia during REM sleep with emergence of complex and vigorous behaviors. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The amount of time spent in poor health at the end of life is increasing. 2 key findings →
Design: narrative review Evidence: high
Full summary, score breakdown and related studies → Original source
We determined the effects of distraction on gait in healthy elderly subjects and Alzheimer's disease (AD) patients. 5 key findings →
Participants: 20 Evidence: low
Full summary, score breakdown and related studies → Original source
Under normal conditions, vivid dream mentation combined with skeletal muscle paralysis characterizes rapid eye movement sleep. 5 key findings →
Evidence: high
Full summary, score breakdown and related studies → Original source
Healthy aging is the process of preserving and enhancing one's independence, physical and mental well-being, and overall quality of life. 5 key findings →
Participants: 25 Evidence: low
Full summary, score breakdown and related studies → Original source
The preliminary findings from this study support the possibility that aerobic fitness is positively associated with the memory performance of those individuals at most genetic risk for Alzheimer disease. 3 key findings →
Participants: 90 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
This research indicates that diet and exercise programs have the potential to improve aspects of cognition and mood in an aging population. 4 key findings →
Participants: 102 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Ageing causes changes to the brain size, vasculature, and cognition. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Senescence is a leading cause of mortality, disability, and non-communicable chronic diseases in older adults. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
The concept of 'cognitive reserve', and a broader theory of 'brain reserve', were originally proposed to help explain epidemiological data indicating that individuals who engaged in higher levels of mental and physical activity via education, occupation and recreation, were at lower risk of developing Alzheimer's disease and other forms of dementia. 4 key findings →
Evidence: low
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Accumulating evidence from animal and human studies supports the notion that physical exercise can enhance neuroplasticity and thus reduce the risk of several neurodegenerative diseases (e.g., dementia). 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Poor diet and obesity are associated with cognitive impairment throughout adulthood, and increased dementia risk in aging. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
The prevention of Alzheimer's disease (AD) has become a real challenge due to its rising prevalence and the lack of an effective cure. 3 key findings →
Evidence: high
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Neurofibrillary tangles (NFT) and β-amyloid plaques are the neurological hallmarks of both Alzheimer's disease and an unusual paralytic illness suffered by Chamorro villagers on the Pacific island of Guam. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
High-fat diet had a wider array of metabolic, cognitive, and neuropathological consequences in AD and MxD females compared to males. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
10 of the 1,888 studies in this tag that have a study page, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,580 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,580 records, built mostly from automated pulls of Europe PMC (62.2% of the library) and OpenAlex (17.8%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.6% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →