28,980 Alzheimer's and dementia studies in plain English, each scored out of 100.
Schizophrenia is characterized by reduced hippocampal volume, decreased dendritic spine density, altered neuroplasticity signaling pathways, and cognitive deficits associated with impaired hippocampal function. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
We examined the effects of voluntary (16 weeks of wheel running) and forced (16 weeks of treadmill running) exercise on memory-related behavior, hippocampal volume, thioflavine-stained plaque number, and soluble Abeta levels in brain tissue in the Tg2576 mouse model of Alzheimer's disease (AD). 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The hippocampus is crucial for normal brain function, especially for the encoding and retrieval of multimodal sensory information. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Impairments in mood and cognitive function are the key brain abnormalities observed in Gulf war illness (GWI), a chronic multisymptom health problem afflicting ∼25% of veterans who served in the Persian Gulf War-1. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Glucocorticoids (GCs) are hormones secreted by the adrenal glands as an endocrine response to stress. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Reduction of cerebral blood flow is an important risk factor for dementia states and other brain dysfunctions. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Ts65Dn, a well-characterized animal model for Down syndrome, has three copies of the distal end of mouse chromosome 16 and therefore has segmental trisomy for orthologs for nearly half of the genes located on human chromosome 21. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Neuropathologic and neuroradiologic studies have reported hippocampal abnormalities in schizophrenics. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Application of magnetic resonance imaging (MRI) techniques reveals that human brain aging varies across cortical regions. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
High alcohol consumption for long periods of time causes significant hippocampal neurodegeneration in rodents. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Age has a powerful effect on enhanced susceptibility to neurodegenerative diseases, including susceptibility to stroke and cognitive impairment (CI) even in optimally healthy individuals. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Proof that blood-brain barrier failure is key to these conditions could provide a target for new treatments to reduce the effects of vascular disease on the brain and prevent cognitive decline and dementia. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Tobacco smoke consists of thousands of compounds including nicotine. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Nitric oxide (NO) is an important signaling molecule that is widely used in the nervous system. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Defining the multiple roles of the mechanistic (formerly 'mammalian') target of rapamycin (mTOR) signalling pathway in neurological diseases has been an exciting and rapidly evolving story of bench-to-bedside translational research that has spanned gene mutation discovery, functional experimental validation of mutations, pharmacological pathway manipulation, and clinical trials. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Each year, 10 million people worldwide survive the neurologic injury associated with a stroke. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Nitric oxide (NO) is a unique biological messenger molecule which mediates diverse physiologic roles. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Low-to-moderate red wine consumption appeared to reduce age-related neurological disorders including macular degeneration, stroke, and cognitive deficits with or without dementia. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Cytokines and chemokines have been implicated in contributing to the initiation, propagation and regulation of immune and inflammatory responses. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Breakdown of cellular membranes is a characteristic feature of neuronal degeneration in acute (stroke) and chronic (senile dementia) neurological disorders. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Glutamate is an essential neurotransmitter regulating brain functions. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Microvascular disease, not macroscopic infarction, was the chief substrate of vascular dementia in this series of cases. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Several studies report that blood pressure is increased in victims of Alzheimer's disease (AD) decades before the onset of the disease. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The close relationship between stroke and dementia is an important health issue. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Brain vasculature is a complex and interconnected network under tight regulatory control that exists in intimate communication with neurons and glia. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
10 of the 7,799 studies in this tag that have a study page, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,980 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,980 records, built mostly from automated pulls of Europe PMC (62.8% of the library) and OpenAlex (17.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,038 records (3.6% of the library) are not peer-reviewed — 966 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →