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Home › Research › Topics › signalling-pathway

signalling-pathway

4 studies tagged signalling-pathway, dated 1999-12-01 to 2021-06-25. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome 2021-06-25
  2. Weighted burden analysis of exome-sequenced late-onset Alzheimer's cases and controls provides further evidence for a role for PSEN1 and suggests involvement of the PI3K/Akt/GSK-3β and WNT signalling pathways 2020-02-05
  3. Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors 2015-08-22

Studies

4 studies carry this tag.

Date range

1999 to 2021

Top journals

  • Annals of human genetics 1
  • Molecular brain 1
  • Nature cell biology 1
  • Scientific reports 1

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Scientific reports 2021-06-25 TREM2 and immune genetics

    The R47H variant of the microglial membrane receptor TREM2 is linked to increased risk of late onset Alzheimer's disease.

  2. Weighted burden analysis of exome-sequenced late-onset Alzheimer's cases and controls provides further evidence for a role for PSEN1 and suggests involvement of the PI3K/Akt/GSK-3β and WNT signalling pathways

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Annals of human genetics 2020-02-05 TREM2 and immune genetics

    Previous studies have implicated common and rare genetic variants as risk factors for late-onset Alzheimer's disease (LOAD).

  3. Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Molecular brain 2015-08-22 Biomarkers

    IIS is functional in astrocytes.

  4. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature cell biology 1999-12-01 Risk genes beyond APOE

    Missense mutations in the human presenilin-1 (PS1) gene, which is found on chromosome 14, cause early-onset familial Alzheimer's disease (FAD).

All topic tags with their study counts