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Home › Research › Topics › secretase

secretase

4 studies tagged secretase, dated 2011-06-01 to 2018-08-16. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Retrograde transport of γ-secretase from endosomes to the trans-Golgi network regulates Aβ42 production 2018-08-16
  2. Plumbagin ameliorates memory dysfunction in streptozotocin induced Alzheimer's disease via activation of Nrf2/ARE pathway and inhibition of β-secretase 2018-03-22
  3. The Alzheimer's Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides 2017-06-01

Studies

4 studies carry this tag.

Date range

2011 to 2018

Top journals

  • Annals of neurology 1
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 1
  • Cell reports 1
  • Journal of neurochemistry 1

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Retrograde transport of γ-secretase from endosomes to the trans-Golgi network regulates Aβ42 production

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neurochemistry 2018-08-16 Biomarkers

    The aberrant metabolism of amyloid-β protein (Aβ) in the human brain has been implicated in the etiology of Alzheimer disease (AD). γ-Secretase is the enzyme that generates various forms of Aβ, such as Aβ40 and Aβ42, the latter being an aggregation-prone toxic peptide that is involved in the pathogenesis of AD.

  2. Plumbagin ameliorates memory dysfunction in streptozotocin induced Alzheimer's disease via activation of Nrf2/ARE pathway and inhibition of β-secretase

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018-03-22 Biomarkers

    Although plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) protects against cerebral ischemia and spinal cord injury-induced oxidative stress and inflammation by activating the nuclear factor-erythroid 2-related factor-2 /antioxidant response element (Nrf2/ARE) pathway, its role in the amelioration of neurodegenerative diseases remains unexplored.

  3. The Alzheimer's Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Cell reports 2017-06-01 Biomarkers

    Alzheimer's disease is characterized by intracerebral deposition of β-amyloid (Aβ).

  4. Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Annals of neurology 2011-06-01 Biomarkers

    These results suggest that some SAD may involve alternative processing of multiple γ-secretase substrates, raising the possibility that the molecular pathogenesis of SAD might involve γ-secretase dysfunction.

All topic tags with their study counts