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Home › Research › Topics › regulates

regulates

6 studies tagged regulates, dated 2013-07-01 to 2018-08-20. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. PU.1 regulates Alzheimer's disease-associated genes in primary human microglia 2018-08-20
  2. Retrograde transport of γ-secretase from endosomes to the trans-Golgi network regulates Aβ42 production 2018-08-16
  3. PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing 2018-08-13

Studies

6 studies carry this tag.

Date range

2013 to 2018

Top journals

  • Journal of neurochemistry 2
  • Cell systems 1
  • Molecular neurodegeneration 1
  • Nature immunology 1
  • PloS one 1

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. PU.1 regulates Alzheimer's disease-associated genes in primary human microglia

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular neurodegeneration 2018-08-20 Genetics

    In the brain, PU.1 is specifically expressed in microglia and recent evidence from genome-wide association studies suggests that reductions in PU.1 contribute to a delayed onset of Alzheimer's disease (AD), possibly through limiting neuroinflammatory responses.

  2. Retrograde transport of γ-secretase from endosomes to the trans-Golgi network regulates Aβ42 production

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neurochemistry 2018-08-16 Biomarkers

    The aberrant metabolism of amyloid-β protein (Aβ) in the human brain has been implicated in the etiology of Alzheimer disease (AD). γ-Secretase is the enzyme that generates various forms of Aβ, such as Aβ40 and Aβ42, the latter being an aggregation-prone toxic peptide that is involved in the pathogenesis of AD.

  3. PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature immunology 2018-08-13 Genetics

    The sensing of microbial genetic material by leukocytes often elicits beneficial pro-inflammatory cytokines, but dysregulated responses can cause severe pathogenesis.

  4. Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging Phenotypes

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Cell systems 2017-03-18 Genetics

    Human age-associated traits, such as cognitive decline, can be highly variable across the population, with some individuals exhibiting traits that are not expected at a given chronological age.

  5. Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PloS one 2016-02-26 Genetics

    Late onset Alzheimer's disease (LOAD) is a genetically complex and clinically heterogeneous disease.

  6. TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neurochemistry 2013-07-01 Genetics

    Frontotemporal lobar degeneration (FTLD) is the second leading cause of dementia in individuals under age 65.

All topic tags with their study counts