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randomized-clinical
4 studies tagged randomized-clinical, dated 2019-01-01 to 2023-06-26. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- A non-pharmacological multi-modal therapy to improve sleep and cognition and reduce mild cognitive impairment risk: Design and methodology of a randomized clinical trial 2023-06-26
- The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial 2022-10-28
- Effect of the Histone Deacetylase Inhibitor FRM-0334 on Progranulin Levels in Patients With Progranulin Gene Haploinsufficiency: A Randomized Clinical Trial 2021-09-01
Studies
4 studies carry this tag.
Date range
2019 to 2023
Top journals
- Contemporary clinical trials 2
- JAMA network open 1
- Journal of Alzheimer's disease : JAD 1
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Aging populations are at increased risk of sleep deficiencies (e.g., insomnia) that are associated with a variety of chronic health risks, including Alzheimer's disease and related dementias (ADRD).
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The PACT study addresses the rapidly increasing prevalence of dementia.
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In a cross-sectional analysis of 26 individuals, bifrontal cortical FDG hypometabolism was associated with worse Clinical Dementia Rating (CDR) plus National Alzheimer's Coordinating Center frontotemporal lobar degeneration sum of boxes score (b = -3.6 × 10-2 standardized uptake value ratio [SUVR] units/CDR units; 95% CI, -4.9 × 10-2 to -2.2 × 10-2; P < .001), high cerebrospinal fluid NfL (b = -9.2 × 10-5 SUVR units/pg NfL/mL; 95% CI, -1.3 × 10-4 to -5.6 × 10-5; P < .001), and high CSF t-tau (-7.2 × 10-4 SUVR units/pg t-tau/mL; 95% CI, -1.4 × 10-3 to -9.5 × 10-5; P = .03).
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Mailings are cost-effective, but direct contact improved recruitment.